| pubmed-article:8710878 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8710878 | lifeskim:mentions | umls-concept:C0385463 | lld:lifeskim |
| pubmed-article:8710878 | lifeskim:mentions | umls-concept:C0021764 | lld:lifeskim |
| pubmed-article:8710878 | lifeskim:mentions | umls-concept:C0206552 | lld:lifeskim |
| pubmed-article:8710878 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:8710878 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:8710878 | lifeskim:mentions | umls-concept:C2698977 | lld:lifeskim |
| pubmed-article:8710878 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:8710878 | pubmed:dateCreated | 1996-9-12 | lld:pubmed |
| pubmed-article:8710878 | pubmed:abstractText | The leptin receptor (OB-R) is a single membrane-spanning protein that mediates the weight regulatory effects of leptin (OB protein). The mutant allele (db) of the OB-R gene encodes a protein with a truncated cytoplasmic domain that is predicted to be functionally inactive. Several mRNA splice variants encoding OB-Rs with different length cytoplasmic domains have been detected in various tissues. Here we demonstrate that the full-length OB-R (predominantly expressed in the hypothalamus), but not a major naturally occurring truncated form or a mutant from found in db/db mice, can mediate activation of signal transducer and activator of transcription (STAT) proteins and stimulate transcription through interleukin 6 responsive gene elements. Reconstitution experiments suggest that, although OB-R mediates intracellular signals with a specificity similar to interleukin 6-type cytokine receptors, signaling appears to be independent of the gp130 signal transducing component of the interleukin 6-type cytokine receptors. | lld:pubmed |
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| pubmed-article:8710878 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8710878 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8710878 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8710878 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8710878 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8710878 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8710878 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8710878 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8710878 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8710878 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8710878 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8710878 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8710878 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8710878 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8710878 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8710878 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8710878 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8710878 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8710878 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8710878 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8710878 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8710878 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8710878 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8710878 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:8710878 | pubmed:author | pubmed-author:KimHH | lld:pubmed |
| pubmed-article:8710878 | pubmed:author | pubmed-author:BaumannHH | lld:pubmed |
| pubmed-article:8710878 | pubmed:author | pubmed-author:WhiteD WDW | lld:pubmed |
| pubmed-article:8710878 | pubmed:author | pubmed-author:TartagliaL... | lld:pubmed |
| pubmed-article:8710878 | pubmed:author | pubmed-author:BailonP SPS | lld:pubmed |
| pubmed-article:8710878 | pubmed:author | pubmed-author:MorellaK KKK | lld:pubmed |
| pubmed-article:8710878 | pubmed:author | pubmed-author:LamC BCB | lld:pubmed |
| pubmed-article:8710878 | pubmed:author | pubmed-author:DembskiMM | lld:pubmed |
| pubmed-article:8710878 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8710878 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:8710878 | pubmed:volume | 93 | lld:pubmed |
| pubmed-article:8710878 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8710878 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8710878 | pubmed:pagination | 8374-8 | lld:pubmed |
| pubmed-article:8710878 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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