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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1996-9-9
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pubmed:abstractText |
We have recently demonstrated that Schizosaccharomyces pombe cells treated with the nucleoside analogue 5-azacytidine (5-azaC) require previously characterised G2 checkpoint mechanisms for survival. Here we present a survey of known DNA repair mutations which defines those genes required for survival in the presence of 5-azaC. Using a combination of single-mutant and epistasis analyses we find that the excision, mismatch and recombinational repair pathways are all required in some degree for the repair of 5-azaC-mediated DNA damage. There are distinct differences in the epistatic interactions of several of the repair mutations with respect to 5-azaC-mediated DNA damage relative to UV-mediated DNA damage.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Azacitidine,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Endodeoxyribonucleases,
http://linkedlifedata.com/resource/pubmed/chemical/Escherichia coli Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fungal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MutS DNA Mismatch-Binding Protein,
http://linkedlifedata.com/resource/pubmed/chemical/MutS protein, E coli,
http://linkedlifedata.com/resource/pubmed/chemical/Nucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/RAD18 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/RAD2 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/RHP51 protein, S pombe,
http://linkedlifedata.com/resource/pubmed/chemical/Rad12 protein, Coprinus cinereus,
http://linkedlifedata.com/resource/pubmed/chemical/Rad51 Recombinase,
http://linkedlifedata.com/resource/pubmed/chemical/SWI4 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Schizosaccharomyces pombe Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0026-8925
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
251
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
483-92
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8709952-Adenosine Triphosphatases,
pubmed-meshheading:8709952-Azacitidine,
pubmed-meshheading:8709952-Bacterial Proteins,
pubmed-meshheading:8709952-DNA Damage,
pubmed-meshheading:8709952-DNA Repair,
pubmed-meshheading:8709952-DNA-Binding Proteins,
pubmed-meshheading:8709952-Drug Resistance, Microbial,
pubmed-meshheading:8709952-Endodeoxyribonucleases,
pubmed-meshheading:8709952-Escherichia coli Proteins,
pubmed-meshheading:8709952-Fungal Proteins,
pubmed-meshheading:8709952-MutS DNA Mismatch-Binding Protein,
pubmed-meshheading:8709952-Mutation,
pubmed-meshheading:8709952-Nucleotides,
pubmed-meshheading:8709952-Rad51 Recombinase,
pubmed-meshheading:8709952-Radiation Tolerance,
pubmed-meshheading:8709952-Recombination, Genetic,
pubmed-meshheading:8709952-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:8709952-Schizosaccharomyces,
pubmed-meshheading:8709952-Schizosaccharomyces pombe Proteins,
pubmed-meshheading:8709952-Sequence Homology, Nucleic Acid,
pubmed-meshheading:8709952-Transcription Factors
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pubmed:year |
1996
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pubmed:articleTitle |
The genetics of the repair of 5-azacytidine-mediated DNA damage in the fission yeast Schizosaccharomyces pombe.
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pubmed:affiliation |
Department of Molecular Biology and Biotechnology, University of Sheffield, U.K.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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