| pubmed-article:8709641 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8709641 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8709641 | lifeskim:mentions | umls-concept:C0680063 | lld:lifeskim |
| pubmed-article:8709641 | lifeskim:mentions | umls-concept:C0870134 | lld:lifeskim |
| pubmed-article:8709641 | lifeskim:mentions | umls-concept:C0229601 | lld:lifeskim |
| pubmed-article:8709641 | lifeskim:mentions | umls-concept:C0031437 | lld:lifeskim |
| pubmed-article:8709641 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:8709641 | pubmed:dateCreated | 1996-9-9 | lld:pubmed |
| pubmed-article:8709641 | pubmed:abstractText | Hematopoietic progenitor cells can be classified as plastic- and stroma-adherent (P+S+), stroma-adherent (P-S+) and non-adherent (P-S-). Both P+S+ and P-S+ populations are detected in delta (delta) culture systems where they produce non-adherent (P-S-) granulocyte-macrophage colony-forming cells (CFU-GM) and erythroid burst-forming units (BFU-E). Here we demonstrate that the plastic-adherent progenitor cells (P delta cells) comprise 5-10 percent of the CD34+, population in adult human marrow. Moreover, they do not express CD3 or CD22 and 88 percent of them are CD38-, 88 percent are CD33- and 74 percent are HLA-DR-. Production of CFU-GM by purified plastic-adherent CD34+, adherent cells was 60 percent of the number produced by recombined CD34+, and CD34- fractions. We have shown also that the plastic-adherent P+S+ cells are the precursors of the stroma-adherent P-S+ cells (S delta cells), day 21 cobblestone-area forming cells (CAFC) and cells capable of sustained hematopoiesis in a modified long-term bone marrow culture system. These observations support the primitive nature of P delta cells and establish a phenotypic sequence of plastic and stroma adherence through stroma adherence to non-adherence in hematopoietic cell development. To further investigate the relationship between P delta cells, S delta cells and long-term culture-initiating cells (LTCIC), we cultured whole mononuclear cell tractions and plastic-adherent cell-depleted mononuclear cell fractions in long-term culture and in the S delta assay. The results indicated the P delta cells were inhibited in the presence of stromal cells. | lld:pubmed |
| pubmed-article:8709641 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8709641 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709641 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8709641 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709641 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709641 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709641 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709641 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709641 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709641 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709641 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709641 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709641 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709641 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709641 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709641 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8709641 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8709641 | pubmed:issn | 0887-6924 | lld:pubmed |
| pubmed-article:8709641 | pubmed:author | pubmed-author:GoldmanJ MJM | lld:pubmed |
| pubmed-article:8709641 | pubmed:author | pubmed-author:GordonM YMY | lld:pubmed |
| pubmed-article:8709641 | pubmed:author | pubmed-author:LewisJ LJL | lld:pubmed |
| pubmed-article:8709641 | pubmed:author | pubmed-author:MarleyS BSB | lld:pubmed |
| pubmed-article:8709641 | pubmed:author | pubmed-author:GrandF HFH | lld:pubmed |
| pubmed-article:8709641 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8709641 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:8709641 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8709641 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8709641 | pubmed:pagination | 1347-53 | lld:pubmed |
| pubmed-article:8709641 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8709641 | pubmed:meshHeading | pubmed-meshheading:8709641-... | lld:pubmed |
| pubmed-article:8709641 | pubmed:meshHeading | pubmed-meshheading:8709641-... | lld:pubmed |
| pubmed-article:8709641 | pubmed:meshHeading | pubmed-meshheading:8709641-... | lld:pubmed |
| pubmed-article:8709641 | pubmed:meshHeading | pubmed-meshheading:8709641-... | lld:pubmed |
| pubmed-article:8709641 | pubmed:meshHeading | pubmed-meshheading:8709641-... | lld:pubmed |
| pubmed-article:8709641 | pubmed:meshHeading | pubmed-meshheading:8709641-... | lld:pubmed |
| pubmed-article:8709641 | pubmed:meshHeading | pubmed-meshheading:8709641-... | lld:pubmed |
| pubmed-article:8709641 | pubmed:meshHeading | pubmed-meshheading:8709641-... | lld:pubmed |
| pubmed-article:8709641 | pubmed:meshHeading | pubmed-meshheading:8709641-... | lld:pubmed |
| pubmed-article:8709641 | pubmed:meshHeading | pubmed-meshheading:8709641-... | lld:pubmed |
| pubmed-article:8709641 | pubmed:meshHeading | pubmed-meshheading:8709641-... | lld:pubmed |
| pubmed-article:8709641 | pubmed:meshHeading | pubmed-meshheading:8709641-... | lld:pubmed |
| pubmed-article:8709641 | pubmed:meshHeading | pubmed-meshheading:8709641-... | lld:pubmed |
| pubmed-article:8709641 | pubmed:meshHeading | pubmed-meshheading:8709641-... | lld:pubmed |
| pubmed-article:8709641 | pubmed:meshHeading | pubmed-meshheading:8709641-... | lld:pubmed |
| pubmed-article:8709641 | pubmed:meshHeading | pubmed-meshheading:8709641-... | lld:pubmed |
| pubmed-article:8709641 | pubmed:meshHeading | pubmed-meshheading:8709641-... | lld:pubmed |
| pubmed-article:8709641 | pubmed:meshHeading | pubmed-meshheading:8709641-... | lld:pubmed |
| pubmed-article:8709641 | pubmed:meshHeading | pubmed-meshheading:8709641-... | lld:pubmed |
| pubmed-article:8709641 | pubmed:meshHeading | pubmed-meshheading:8709641-... | lld:pubmed |
| pubmed-article:8709641 | pubmed:meshHeading | pubmed-meshheading:8709641-... | lld:pubmed |
| pubmed-article:8709641 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8709641 | pubmed:articleTitle | Phenotype and progeny of primitive adherent human hematopoietic progenitors. | lld:pubmed |
| pubmed-article:8709641 | pubmed:affiliation | LRF Centre for Adult Leukaemia, Royal Postgraduate Medical School, London, UK. | lld:pubmed |
| pubmed-article:8709641 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8709641 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709641 | lld:pubmed |
