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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1996-9-10
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pubmed:abstractText |
A new ligand (Ts kappa) of the apamin binding site on rat brain synaptosomes (K0.5 = 300 pM) was purified and characterized from the venom of Tityus serrulatus. It is a polypeptide toxin of 35 amino acid residues, with three disulfide bridges. Its cDNA was amplified from a venom gland cDNA library and the nucleotide sequence determined. A model of Ts kappa was constructed by amino acid replacement using charybdotoxin structure as determined by 1H nuclear magnetic resonance as starting model.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apamin,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Neurotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Scorpion Venoms,
http://linkedlifedata.com/resource/pubmed/chemical/apamin receptor,
http://linkedlifedata.com/resource/pubmed/chemical/tityustoxin
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
390
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
81-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8706835-Amino Acid Sequence,
pubmed-meshheading:8706835-Animals,
pubmed-meshheading:8706835-Apamin,
pubmed-meshheading:8706835-Base Sequence,
pubmed-meshheading:8706835-Brain,
pubmed-meshheading:8706835-DNA, Complementary,
pubmed-meshheading:8706835-DNA Primers,
pubmed-meshheading:8706835-Ligands,
pubmed-meshheading:8706835-Models, Molecular,
pubmed-meshheading:8706835-Molecular Sequence Data,
pubmed-meshheading:8706835-Neurotoxins,
pubmed-meshheading:8706835-Peptides,
pubmed-meshheading:8706835-Polymerase Chain Reaction,
pubmed-meshheading:8706835-Potassium Channels,
pubmed-meshheading:8706835-Protein Conformation,
pubmed-meshheading:8706835-Rats,
pubmed-meshheading:8706835-Recombinant Proteins,
pubmed-meshheading:8706835-Scorpion Venoms,
pubmed-meshheading:8706835-Scorpions,
pubmed-meshheading:8706835-Sequence Homology, Amino Acid,
pubmed-meshheading:8706835-Synaptosomes
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pubmed:year |
1996
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pubmed:articleTitle |
Characterization of a new peptide from Tityus serrulatus scorpion venom which is a ligand of the apamin-binding site.
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pubmed:affiliation |
Laboratoire de Biochimie, URA 1455 du Centre National de la Recherche Scientifique, Institut Fédératif Jean Roche, Faculté de Médecine Nord, Marseille, France.
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pubmed:publicationType |
Journal Article,
Comparative Study
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