| pubmed-article:8706030 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8706030 | lifeskim:mentions | umls-concept:C0006142 | lld:lifeskim |
| pubmed-article:8706030 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8706030 | lifeskim:mentions | umls-concept:C0034802 | lld:lifeskim |
| pubmed-article:8706030 | lifeskim:mentions | umls-concept:C0069515 | lld:lifeskim |
| pubmed-article:8706030 | lifeskim:mentions | umls-concept:C1704824 | lld:lifeskim |
| pubmed-article:8706030 | lifeskim:mentions | umls-concept:C0681916 | lld:lifeskim |
| pubmed-article:8706030 | lifeskim:mentions | umls-concept:C0750572 | lld:lifeskim |
| pubmed-article:8706030 | lifeskim:mentions | umls-concept:C0680844 | lld:lifeskim |
| pubmed-article:8706030 | lifeskim:mentions | umls-concept:C0392762 | lld:lifeskim |
| pubmed-article:8706030 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:8706030 | pubmed:dateCreated | 1996-9-10 | lld:pubmed |
| pubmed-article:8706030 | pubmed:abstractText | Epidermal growth factor receptor (EGFR) expression by human breast cancer has been shown to predict poor patient outcome, as has amplification of the c-erbB-2 proto-oncogene. We have developed a quantitative immunohistochemical method for measuring protein levels of both receptors and have applied this to a series of 123 breast primaries. We find EGFR expression is substantially lower than normal in nearly all breast cancers (97%). Quantification of p185erbB-2 indicates overexpression in 91% of the tumors. Two separate tumor populations are apparent with levels of c-erbB-2 expression ranging from 0.33 to 19 and 45 to 480 times normal, respectively. Within the lower population, p185erbB-2 expression is inversely related to EGFR expression (rank correlation, P < 0.0005). Using fluorescent in situ hybridization we show that tumors in the latter population have c-erbB-2 amplification and that amplification is restricted to this group. Our findings indicate that significant overexpression of p185erbB-2 occurs in the absence of amplification; these lower levels of expression may have functional significance. Fifty-three patients underwent in vivo bromodeoxyuridine labeling, allowing flow cytometric analysis of tumor cell cycle kinetics. EGFR expression correlates directly to the labeling index (P = 0.011) and indirectly to potential doubling time (P = 0.010), but not to the duration of the S-phase (P = 0.502). Conversely, p185erbB-2 expression does not relate to indices of proliferation. Our results have important implications for the use of both receptor types as therapeutic targets. | lld:pubmed |
| pubmed-article:8706030 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8706030 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8706030 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8706030 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8706030 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8706030 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8706030 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8706030 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:8706030 | pubmed:author | pubmed-author:SmithGG | lld:pubmed |
| pubmed-article:8706030 | pubmed:author | pubmed-author:ReevesJ RJR | lld:pubmed |
| pubmed-article:8706030 | pubmed:author | pubmed-author:KeithW NWN | lld:pubmed |
| pubmed-article:8706030 | pubmed:author | pubmed-author:StantonP DPD | lld:pubmed |
| pubmed-article:8706030 | pubmed:author | pubmed-author:CookeT GTG | lld:pubmed |
| pubmed-article:8706030 | pubmed:author | pubmed-author:OzanneB WBW | lld:pubmed |
| pubmed-article:8706030 | pubmed:author | pubmed-author:BehringerF... | lld:pubmed |
| pubmed-article:8706030 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8706030 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8706030 | pubmed:volume | 56 | lld:pubmed |
| pubmed-article:8706030 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8706030 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8706030 | pubmed:pagination | 3823-30 | lld:pubmed |
| pubmed-article:8706030 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:8706030 | pubmed:meshHeading | pubmed-meshheading:8706030-... | lld:pubmed |
| pubmed-article:8706030 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8706030 | pubmed:articleTitle | Quantitative estimation of epidermal growth factor receptor and c-erbB-2 in human breast cancer. | lld:pubmed |
| pubmed-article:8706030 | pubmed:affiliation | University Department of Surgery, Glasgow Royal Infirmary, Scotland. | lld:pubmed |
| pubmed-article:8706030 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8706030 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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