| pubmed-article:8705094 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8705094 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
| pubmed-article:8705094 | lifeskim:mentions | umls-concept:C1708335 | lld:lifeskim |
| pubmed-article:8705094 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:8705094 | lifeskim:mentions | umls-concept:C0008018 | lld:lifeskim |
| pubmed-article:8705094 | lifeskim:mentions | umls-concept:C0038836 | lld:lifeskim |
| pubmed-article:8705094 | lifeskim:mentions | umls-concept:C0055147 | lld:lifeskim |
| pubmed-article:8705094 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:8705094 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:8705094 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8705094 | pubmed:dateCreated | 1996-9-9 | lld:pubmed |
| pubmed-article:8705094 | pubmed:abstractText | The aim of the present investigation was to examine the effect of a 1-week oral administration of the anti-allergic drug cetirizine on healthy volunteer neutrophil chemotaxis and superoxide anion (O2-) production. Eight male volunteers were selected after clinical examination and laboratory tests. Neutrophils were isolated from peripheral blood using a discontinuous density gradient. Spontaneous migration and platelet activating factor (PAF, 10(-6) and 10(-8) M) or zymosan-activated plasma (ZAP)-induced chemotaxis were studied in a 48-well microchemotaxis chamber. Basal and phorbol 12-myristate 13-acetate (PMA, 30 nM) stimulated O2- production were measured spectro-photometrically. Cetirizine (10 mg per day) was given orally during 1 week. Both neutrophil chemotaxis and O2- production were assessed before and 2 h, 24 h, and 1 week after orally administered cetirizine. Plasma cetirizine levels were monitored by high performance liquid chromatography (HPLC) with ultraviolet detection. Spontaneous neutrophil migration and PAF-or ZAP-induced chemotaxis showed no significant variation before or at various intervals after the initiation of treatment with cetirizine. Basal and PMA-stimulated neutrophil O2-production was also not affected by cetirizine. The maximum concentration attained by cetirizine (Cmax) was 293 +/- 38 ng/ml and generally peaked (Tmax) within 1.9 +/- 0.7 h. We conclude that the administration of cetirizine for 1 week does not alter human neutrophil chemotaxis and O2- production. | lld:pubmed |
| pubmed-article:8705094 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8705094 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8705094 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8705094 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8705094 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8705094 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8705094 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8705094 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8705094 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8705094 | pubmed:issn | 0946-1965 | lld:pubmed |
| pubmed-article:8705094 | pubmed:author | pubmed-author:BozzaP TPT | lld:pubmed |
| pubmed-article:8705094 | pubmed:author | pubmed-author:Castro-Faria-... | lld:pubmed |
| pubmed-article:8705094 | pubmed:author | pubmed-author:De NucciGG | lld:pubmed |
| pubmed-article:8705094 | pubmed:author | pubmed-author:Condino-NetoA... | lld:pubmed |
| pubmed-article:8705094 | pubmed:author | pubmed-author:MuscaraM NMN | lld:pubmed |
| pubmed-article:8705094 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8705094 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:8705094 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8705094 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8705094 | pubmed:pagination | 96-100 | lld:pubmed |
| pubmed-article:8705094 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:8705094 | pubmed:meshHeading | pubmed-meshheading:8705094-... | lld:pubmed |
| pubmed-article:8705094 | pubmed:meshHeading | pubmed-meshheading:8705094-... | lld:pubmed |
| pubmed-article:8705094 | pubmed:meshHeading | pubmed-meshheading:8705094-... | lld:pubmed |
| pubmed-article:8705094 | pubmed:meshHeading | pubmed-meshheading:8705094-... | lld:pubmed |
| pubmed-article:8705094 | pubmed:meshHeading | pubmed-meshheading:8705094-... | lld:pubmed |
| pubmed-article:8705094 | pubmed:meshHeading | pubmed-meshheading:8705094-... | lld:pubmed |
| pubmed-article:8705094 | pubmed:meshHeading | pubmed-meshheading:8705094-... | lld:pubmed |
| pubmed-article:8705094 | pubmed:meshHeading | pubmed-meshheading:8705094-... | lld:pubmed |
| pubmed-article:8705094 | pubmed:meshHeading | pubmed-meshheading:8705094-... | lld:pubmed |
| pubmed-article:8705094 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8705094 | pubmed:articleTitle | The effect of a 1-week administration of cetirizine on the chemotaxis and superoxide anion production of neutrophils from healthy volunteers. | lld:pubmed |
| pubmed-article:8705094 | pubmed:affiliation | Department of Pediatrics, Faculty of Medical Sciences, State University of Campinas, Brazil. | lld:pubmed |
| pubmed-article:8705094 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8705094 | pubmed:publicationType | Clinical Trial | lld:pubmed |
