Linked Life Data

8705094

Source:http://linkedlifedata.com/resource/pubmed/id/8705094

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1996-9-9
pubmed:abstractText
The aim of the present investigation was to examine the effect of a 1-week oral administration of the anti-allergic drug cetirizine on healthy volunteer neutrophil chemotaxis and superoxide anion (O2-) production. Eight male volunteers were selected after clinical examination and laboratory tests. Neutrophils were isolated from peripheral blood using a discontinuous density gradient. Spontaneous migration and platelet activating factor (PAF, 10(-6) and 10(-8) M) or zymosan-activated plasma (ZAP)-induced chemotaxis were studied in a 48-well microchemotaxis chamber. Basal and phorbol 12-myristate 13-acetate (PMA, 30 nM) stimulated O2- production were measured spectro-photometrically. Cetirizine (10 mg per day) was given orally during 1 week. Both neutrophil chemotaxis and O2- production were assessed before and 2 h, 24 h, and 1 week after orally administered cetirizine. Plasma cetirizine levels were monitored by high performance liquid chromatography (HPLC) with ultraviolet detection. Spontaneous neutrophil migration and PAF-or ZAP-induced chemotaxis showed no significant variation before or at various intervals after the initiation of treatment with cetirizine. Basal and PMA-stimulated neutrophil O2-production was also not affected by cetirizine. The maximum concentration attained by cetirizine (Cmax) was 293 +/- 38 ng/ml and generally peaked (Tmax) within 1.9 +/- 0.7 h. We conclude that the administration of cetirizine for 1 week does not alter human neutrophil chemotaxis and O2- production.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0946-1965
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
96-100
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
The effect of a 1-week administration of cetirizine on the chemotaxis and superoxide anion production of neutrophils from healthy volunteers.
pubmed:affiliation
Department of Pediatrics, Faculty of Medical Sciences, State University of Campinas, Brazil.
pubmed:publicationType
Journal Article, Clinical Trial