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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1996-9-11
|
| pubmed:abstractText |
Between 1986 and 1995, 19 patients with Philadelphia chromosome-positive (Ph + ) acute lymphoblastic leukemia underwent 20 autologous (n = 9) or allogeneic (n = 11) blood or marrow transplant procedures in first (n = 12) or second (n = 3) remission, or in relapse (n = 5). Four patients died due to transplant-related causes, 11 relapsed at 3-39 months, one survives with disease which did not remit after transplant, and three are alive in continuous remission at 1, 26 and 65 months. Two of the relapsing patients are alive; one autografted patient after an allograft in second remission and one allografted patient after a donor leukocyte infusion. The projected overall survival is 37.5% at 3 years and 12.5% at 5 years. The 3-year probabilities of relapse and disease-free survival for autografted patients are 65.9% and 25.6% respectively, and for allografted patients, 63.4% and 21.8% respectively. The stage of the disease at the time of transplant or the type of transplant did not affect the outcome significantly, and late relapses beyond 3 years were seen after allogeneic as well as autologous transplantation. In our experience, the outcome of patients with Ph + acute lymphoblastic leukemia continues to be poor despite high-dose therapy due to high relapse rates, and the development of additional measures to enhance the antileukemic efficacy of bone marrow transplantation is necessary.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0268-3369
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
17
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
365-9
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8704688-Acute Disease,
pubmed-meshheading:8704688-Adolescent,
pubmed-meshheading:8704688-Adult,
pubmed-meshheading:8704688-Bone Marrow Transplantation,
pubmed-meshheading:8704688-Child,
pubmed-meshheading:8704688-Child, Preschool,
pubmed-meshheading:8704688-Disease-Free Survival,
pubmed-meshheading:8704688-Female,
pubmed-meshheading:8704688-Humans,
pubmed-meshheading:8704688-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:8704688-Male,
pubmed-meshheading:8704688-Middle Aged,
pubmed-meshheading:8704688-Probability,
pubmed-meshheading:8704688-Prognosis,
pubmed-meshheading:8704688-Prospective Studies,
pubmed-meshheading:8704688-Recurrence,
pubmed-meshheading:8704688-Transplantation, Autologous,
pubmed-meshheading:8704688-Transplantation, Homologous
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Bone marrow transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia.
|
| pubmed:affiliation |
Leukaemia Unit, Royal Marsden Hospital, Surrey, UK.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|