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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5280
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pubmed:dateCreated |
1996-10-1
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pubmed:abstractText |
The maintenance and significance of the complex populations of microbes present in the mammalian intestine are poorly understood. Comparison of conventionally housed and germ-free NMRI mice revealed that production of fucosylated glycoconjugates and an alpha1, 2-fucosyltransferase messenger RNA in the small-intestinal epithelium requires the normal microflora. Colonization of germ-free mice with Bacteroides thetaiotaomicron, a component of this flora, restored the fucosylation program, whereas an isogenic strain carrying a transposon insertion that disrupts its ability to use L-fucose as a carbon source did not. Simplified models such as this should aid the study of open microbial ecosystems.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
273
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1380-3
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8703071-Animals,
pubmed-meshheading:8703071-Bacteroides,
pubmed-meshheading:8703071-Base Sequence,
pubmed-meshheading:8703071-Cell Differentiation,
pubmed-meshheading:8703071-Cell Lineage,
pubmed-meshheading:8703071-Colony Count, Microbial,
pubmed-meshheading:8703071-Ecosystem,
pubmed-meshheading:8703071-Fucose,
pubmed-meshheading:8703071-Fucosyltransferases,
pubmed-meshheading:8703071-Germ-Free Life,
pubmed-meshheading:8703071-Glycoconjugates,
pubmed-meshheading:8703071-Intestinal Mucosa,
pubmed-meshheading:8703071-Intestine, Small,
pubmed-meshheading:8703071-Male,
pubmed-meshheading:8703071-Mice,
pubmed-meshheading:8703071-Mice, Inbred Strains,
pubmed-meshheading:8703071-Molecular Sequence Data,
pubmed-meshheading:8703071-Polymerase Chain Reaction,
pubmed-meshheading:8703071-RNA, Messenger
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pubmed:year |
1996
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pubmed:articleTitle |
A model of host-microbial interactions in an open mammalian ecosystem.
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pubmed:affiliation |
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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