Linked Life Data

8700952

Source:http://linkedlifedata.com/resource/pubmed/id/8700952

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1996-9-3
pubmed:abstractText
Electrophysiological and biochemical evidence suggests that cAMP mediates sweet taste transduction. Neural recordings from anesthetized rats and in vitro preparations demonstrate that membrane-per-meable cAMP analogues mimic the effects of sucrose and artificial sweetners. We presented solutions of sodium 8-(4-chlorophenylthio)-adenosine 3'-5'-cyclic monophosphate (8cpt-cAMP), a water-soluble, membrane-permeable cAMP analogue to freely behaving rats in short-term lickometer tests. Rats licked significantly less to 8cpt-cAMP than to sucrose or palatable saccharin solutions. Rats could taste 8cpt-cAMP solutions, however, because they licked less to 8cpt-cAMP in mixture with sucrose than to sucrose alone. Because 8cpt-cAMP decreased licking when mixed with sucrose, we conclude that the taste of 8cpt-cAMP is aversive, not sweet, to freely behaving rats.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0031-9384
pubmed:author
pubmed:issnType
Print
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
495-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Cyclic AMP tastes aversive, not sweet, to rats.
pubmed:affiliation
E. W. Bourne Behavioral Research Laboratory, Department of Psychiatry, Cornell University Medical College, White Plains, NY 10605, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't