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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1996-9-5
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pubmed:databankReference |
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pubmed:abstractText |
RNA editing by adenosine deamination in brain-expressed pre-mRNAs for glutamate receptor (GluR) subunits alters gene-specified codons for functionally critical positions, such as the channel's Q/R site. We show by transcript analysis of minigenes transiently expressed in PC-12 cells that, in contrast to GluR-B pre-mRNA, where the two editing sites (Q/R and R/G) require base pairing with nearby intronic editing site complementary sequences (ECSs), editing in GluR5 and GluR6 pre-mRNAs recruits an ECS located as far as 1900 nucleotides distal to the Q/R site. The exon-intron duplex structure of the GluR5 and GluR6 pre-mRNAs appears to be a substrate of double-stranded RNA-specific adenosine deaminase. This enzyme when coexpressed in HEK 293 cells preferentially targets the adenosine of the Q/R site and of an unpaired position in the ECS which is highly edited in brain.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8700852-15335736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8700852-1717158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8700852-2158863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8700852-2398905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8700852-2434241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8700852-2482418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8700852-3621347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8700852-3659919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8700852-3670292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8700852-6163133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8700852-7512622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8700852-7523595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8700852-7527340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8700852-7539962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8700852-7552165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8700852-7681676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8700852-7721757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8700852-7862132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8700852-7870177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8700852-7878468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8700852-7972084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8700852-7992055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8700852-8210177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8700852-8241470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8700852-8269514
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1875-80
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8700852-Adenosine,
pubmed-meshheading:8700852-Amino Acid Sequence,
pubmed-meshheading:8700852-Animals,
pubmed-meshheading:8700852-Base Sequence,
pubmed-meshheading:8700852-Brain,
pubmed-meshheading:8700852-DNA Primers,
pubmed-meshheading:8700852-Hydrogen Bonding,
pubmed-meshheading:8700852-Introns,
pubmed-meshheading:8700852-Mice,
pubmed-meshheading:8700852-Molecular Sequence Data,
pubmed-meshheading:8700852-Nucleic Acid Conformation,
pubmed-meshheading:8700852-PC12 Cells,
pubmed-meshheading:8700852-RNA, Double-Stranded,
pubmed-meshheading:8700852-RNA Editing,
pubmed-meshheading:8700852-RNA Precursors,
pubmed-meshheading:8700852-Rats,
pubmed-meshheading:8700852-Receptors, Kainic Acid
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pubmed:year |
1996
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pubmed:articleTitle |
Q/R site editing in kainate receptor GluR5 and GluR6 pre-mRNAs requires distant intronic sequences.
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pubmed:affiliation |
Laboratory for Molecular Neuroendocrinololgy, Zentrum für Molekulare Biologie, Heidelberg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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