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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6591
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pubmed:dateCreated |
1996-9-3
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pubmed:abstractText |
The production of amino acids and their condensation to polypeptides under plausibly prebiotic conditions have long been known. But despite the central importance of molecular self-replication in the origin of life, the feasibility of peptide self-replication has not been established experimentally. Here we report an example of a self-replicating peptide. We show that a 32-residue alpha-helical peptide based on the leucine-zipper domain of the yeast transcription factor GCN4 can act autocatalytically in templating its own synthesis by accelerating the thioester-promoted amide-bond condensation of 15- and 17-residue fragments in neutral, dilute aqueous solutions. The self-replication process displays parabolic growth pattern with the initial rates of product formation correlating with the square-foot of initial template concentration.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
382
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
525-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8700225-Amino Acid Sequence,
pubmed-meshheading:8700225-Catalysis,
pubmed-meshheading:8700225-DNA-Binding Proteins,
pubmed-meshheading:8700225-Fungal Proteins,
pubmed-meshheading:8700225-Leucine Zippers,
pubmed-meshheading:8700225-Molecular Sequence Data,
pubmed-meshheading:8700225-Peptide Biosynthesis,
pubmed-meshheading:8700225-Peptides,
pubmed-meshheading:8700225-Protein Kinases,
pubmed-meshheading:8700225-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:8700225-Templates, Genetic,
pubmed-meshheading:8700225-Transcription Factors
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pubmed:year |
1996
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pubmed:articleTitle |
A self-replicating peptide.
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pubmed:affiliation |
Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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