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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1996-9-3
|
| pubmed:abstractText |
We have shown that normal C57BL/6J mice are moderately resistant to infection with murine cytomegalovirus (MCMV) and that this resistance is impaired by prior infection with LP-BM5 MuLV, which causes a disease (MAIDS) similar to early HIV-induced disease. This study investigates macrophage function in MAIDS+ mice challenged with MCMV. MAIDS reduces the influx of cells into the peritoneal cavity seen in normal C57BL/6J mice 6 days after MCMV infection. The infiltrates contained cells that resembled activated macrophages, as they took up colloidal gold, expressed the macrophage marker Mac-1, had high levels of acid phosphatase activity, and were lymphocytostatic when co-cultured with activated T cells. MAIDS+ mice had a higher percentage of cells able to take up colloidal gold and higher acid phosphatase activity per cell. The cells were also more lymphocytostatic and produced higher levels of interleukin-1 and tumor necrosis factor-alpha on days 4 and 6 after MCMV infection. Hence, MAIDS enhances baseline and induced macrophage activity, but depresses infiltration into the site of inflammation.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0741-5400
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
60
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
44-50
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8699122-Acid Phosphatase,
pubmed-meshheading:8699122-Animals,
pubmed-meshheading:8699122-Cells, Cultured,
pubmed-meshheading:8699122-Coculture Techniques,
pubmed-meshheading:8699122-Cytomegalovirus,
pubmed-meshheading:8699122-Cytomegalovirus Infections,
pubmed-meshheading:8699122-Female,
pubmed-meshheading:8699122-Flow Cytometry,
pubmed-meshheading:8699122-Inflammation,
pubmed-meshheading:8699122-Interleukin-1,
pubmed-meshheading:8699122-Lymphocyte Activation,
pubmed-meshheading:8699122-Macrophage Activation,
pubmed-meshheading:8699122-Macrophage-1 Antigen,
pubmed-meshheading:8699122-Macrophages, Peritoneal,
pubmed-meshheading:8699122-Mice,
pubmed-meshheading:8699122-Mice, Inbred C57BL,
pubmed-meshheading:8699122-Murine Acquired Immunodeficiency Syndrome,
pubmed-meshheading:8699122-T-Lymphocytes,
pubmed-meshheading:8699122-Time Factors,
pubmed-meshheading:8699122-Tumor Necrosis Factor-alpha
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
The inflammatory macrophage response to MCMV in mice with a retroviral immunodeficiency syndrome (MAIDS).
|
| pubmed:affiliation |
Department of Microbiology, University of Western Australia, Nedlands, Australia.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|