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| pubmed-article:8698851 | lifeskim:mentions | umls-concept:C0021051 | lld:lifeskim |
| pubmed-article:8698851 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8698851 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:8698851 | lifeskim:mentions | umls-concept:C0254610 | lld:lifeskim |
| pubmed-article:8698851 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:8698851 | lifeskim:mentions | umls-concept:C0596873 | lld:lifeskim |
| pubmed-article:8698851 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8698851 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8698851 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:8698851 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:8698851 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8698851 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8698851 | pubmed:dateCreated | 1996-9-5 | lld:pubmed |
| pubmed-article:8698851 | pubmed:abstractText | The newly identified cytokine, IL-15 enhanced antigen-induced proliferation of PBMC obtained from HIV-1-seropositive subjects. When compared to IL-2 which enhanced both spontaneous and antigen-induced lymphocyte proliferative responses, IL-15 rarely increased spontaneous lymphocyte proliferation. Additionally, in cultures of lymphocytes obtained from 15 HIV-1-infected patients with < 300 circulating CD4- lymphocytes/microliter IL-15 induced significant HIV-1 expression (46, 21, and 71 pg/ml) in only 3 of 15 experiments and IL-2 induced significant HIV-1 expression (range 16- > 5000 pg/ml) in 11 of 15 experiments (P < 0.01, Fischer's exact test). Simultaneous assays of cytokine-induced spontaneous lymphocyte proliferation and HIV-1 expression revealed similar dose-response relationships for induction of HIV-1 and lymphocyte proliferation by IL-2. Thus, IL-15 helps to correct the impaired proliferative response of CD4+ lymphocytes from HIV-1-infected persons without the mitogenic effect of IL-2 that also may induce HIV-1 expression. | lld:pubmed |
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| pubmed-article:8698851 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8698851 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8698851 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:8698851 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8698851 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8698851 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:8698851 | pubmed:author | pubmed-author:BoopW CWC | lld:pubmed |
| pubmed-article:8698851 | pubmed:author | pubmed-author:ThomasE KEK | lld:pubmed |
| pubmed-article:8698851 | pubmed:author | pubmed-author:PatkiA HAH | lld:pubmed |
| pubmed-article:8698851 | pubmed:author | pubmed-author:LedermanM MMM | lld:pubmed |
| pubmed-article:8698851 | pubmed:author | pubmed-author:Yen-Lieberman... | lld:pubmed |
| pubmed-article:8698851 | pubmed:author | pubmed-author:Quiñones-Mate... | lld:pubmed |
| pubmed-article:8698851 | pubmed:author | pubmed-author:DorazioDD | lld:pubmed |
| pubmed-article:8698851 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8698851 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8698851 | pubmed:volume | 98 | lld:pubmed |
| pubmed-article:8698851 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8698851 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8698851 | pubmed:pagination | 616-21 | lld:pubmed |
| pubmed-article:8698851 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8698851 | pubmed:meshHeading | pubmed-meshheading:8698851-... | lld:pubmed |
| pubmed-article:8698851 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8698851 | pubmed:articleTitle | Activation of antigen-induced lymphocyte proliferation by interleukin-15 without the mitogenic effect of interleukin-2 that may induce human immunodeficiency virus-1 expression. | lld:pubmed |
| pubmed-article:8698851 | pubmed:affiliation | Department of Medicine, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Ohio 44106, USA. | lld:pubmed |
| pubmed-article:8698851 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8698851 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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