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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0021051,
umls-concept:C0021756,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0205263,
umls-concept:C0254610,
umls-concept:C0596873,
umls-concept:C1280500,
umls-concept:C1879547,
umls-concept:C2911684
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pubmed:issue |
3
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pubmed:dateCreated |
1996-9-5
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pubmed:abstractText |
The newly identified cytokine, IL-15 enhanced antigen-induced proliferation of PBMC obtained from HIV-1-seropositive subjects. When compared to IL-2 which enhanced both spontaneous and antigen-induced lymphocyte proliferative responses, IL-15 rarely increased spontaneous lymphocyte proliferation. Additionally, in cultures of lymphocytes obtained from 15 HIV-1-infected patients with < 300 circulating CD4- lymphocytes/microliter IL-15 induced significant HIV-1 expression (46, 21, and 71 pg/ml) in only 3 of 15 experiments and IL-2 induced significant HIV-1 expression (range 16- > 5000 pg/ml) in 11 of 15 experiments (P < 0.01, Fischer's exact test). Simultaneous assays of cytokine-induced spontaneous lymphocyte proliferation and HIV-1 expression revealed similar dose-response relationships for induction of HIV-1 and lymphocyte proliferation by IL-2. Thus, IL-15 helps to correct the impaired proliferative response of CD4+ lymphocytes from HIV-1-infected persons without the mitogenic effect of IL-2 that also may induce HIV-1 expression.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8698851-1395102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8698851-1715888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8698851-2162775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8698851-2582258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8698851-2974045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8698851-3489767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8698851-6308051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8698851-7479922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8698851-7561680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8698851-7646637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8698851-8178155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8698851-8409454
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
98
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
616-21
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8698851-Adult,
pubmed-meshheading:8698851-CD4-Positive T-Lymphocytes,
pubmed-meshheading:8698851-Female,
pubmed-meshheading:8698851-HIV-1,
pubmed-meshheading:8698851-Humans,
pubmed-meshheading:8698851-Interleukin-15,
pubmed-meshheading:8698851-Interleukin-2,
pubmed-meshheading:8698851-Interleukins,
pubmed-meshheading:8698851-Lymphocyte Activation,
pubmed-meshheading:8698851-Male,
pubmed-meshheading:8698851-Middle Aged
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pubmed:year |
1996
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pubmed:articleTitle |
Activation of antigen-induced lymphocyte proliferation by interleukin-15 without the mitogenic effect of interleukin-2 that may induce human immunodeficiency virus-1 expression.
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pubmed:affiliation |
Department of Medicine, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Ohio 44106, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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