Linked Life Data

8697922

Source:http://linkedlifedata.com/resource/pubmed/id/8697922

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1996-9-5
pubmed:abstractText
In order to test the defect of luteinizing hormone (LH) pulses and its relationship with sexual development in patients with idiopathic hypogonadotropic hypogonadism (IHH), fourteen male IHH patients and five healthy adult men were investigated. Blood samples were withdrawn at 10 minute intervals for 24h for analysis of LH pulse. LH pulse frequency ranged from 0-13 pulses/24h. Testosterone (T) level was 1.3-8.7 nmol/L in the 14 IHH patients and higher in the 5 healthy controls (all P < 0.01). Two of the patients with IHH had no detectable LH pulsations (apulsatile pattern), no history of puberty and a small testicular volume of less than 1ml. Most of the IHH patients (n = 9) had less pulse frequency (4-13 pulses/24h) and lower mean amplitude (1.3-2.2IU/L) than the healthy controls (14-20 pulses/24h and 3.81-2.46IU/L, P < 0.01). A patient with IHH had 10 pulses/24h and more or less the same mean amplitude (4.2 +/- 1IU/L) as the healthy controls; his T level was the lowest among the 14 patients due probably to biological inactivity of LH. Two IHH patients had detectable LH pulsations with normal mean amplitude (P > 0.05) present predominantly during the night, this pattern of LH pulse resembles that of peripuberty boy. Our results indicate that (1) LH pulse pattern varies widely among IHH patients and it is related to the sex characteristics; (2) frequency of LH pulses is essential for sexual development. but adequate amplitude is more important in this respect.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0578-1426
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
587-90
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
[Analysis of luteinizing hormone pulses in men with idiopathic hypogonadotropic hypogonadism].
pubmed:affiliation
Department of Endocrinology, General Hospital of Chinese PLA, Beijing.
pubmed:publicationType
Journal Article, English Abstract