Linked Life Data

8697902

Source:http://linkedlifedata.com/resource/pubmed/id/8697902

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1996-9-5
pubmed:abstractText
The present study examined the roles of amygdala alpha 1 and beta noradrenergic receptors in memory formation as well as their involvement in the memory enhancing effect of peripheral epinephrine (E). Male Sprague-Dawley rats with cannulae implanted into the amygdala were trained on the one-trial inhibitory avoidance task and tested for retention 24 hrs later. Immediately after training, they received various treatments to alter amygdala noradrenergic functions and/or peripheral adrenergic functions. Separate groups of animals were decapitated 10 min after training for assays of monoamine levels in various brain regions by the HPLC-EC method. Results indicated that, when infused into the amygdala immediately after training, isoproterenol and 8-bromo-cAMP enhanced retention, while propranolol impaired retention. On the other hand, phenylephrine or prazosin failed to produce statistically significant effects. Posttraining intra-amygdala infusion of propranolol, but not prazosin, abolished the memory enhancing effects of norepinephrine (NE) infused into the amygdala or E given subcutaneously to the adrenal demedullated rats. Depletion of amygdala NE by the selective neurotoxin DSP-4 also abolished the memory modulatory effects of E. These findings support that amygdala noradrenergic beta, but not alpha 1, receptors are involved in both central and peripheral memory modulatory processes. However, since the postmortem tissue NE levels in the amygdala and other brain regions did not differ among various groups, the inhibitory avoidance training and peripheral E may only activate a transient functional increase in the amygdala NE activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0304-4920
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
81-91
pubmed:dateRevised
2009-8-12
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
The role of amygdala norepinephrine in memory formation: involvement in the memory enhancing effect of peripheral epinephrine.
pubmed:affiliation
Department of Psychology, National Taiwan University, Taipei, Taiwan, Republic of China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't