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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1996-8-29
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pubmed:abstractText |
The interactions of platelets and liposomes with the tripeptide arginine-glycine-aspartic acid (RGD) as a surface ligand (RGD liposomes) were studied. The results suggest that the presence of the RGD ligand on the liposomes results in receptor-mediated mixing of lipid and aqueous contents of the liposomes and platelets. Mixing of the lipid and aqueous contents of RGD liposomes with platelets is approximately 4-9 times and 3-4 times greater than that for unlabeled liposomes, respectively. Measurements of the cytoplasmic free Ca2+ concentration in platelets, [Ca2+]i, show that the RGD liposomes have little effect on [Ca2+]i.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0006-291X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
224
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
242-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8694820-Animals,
pubmed-meshheading:8694820-Blood Platelets,
pubmed-meshheading:8694820-Calcium,
pubmed-meshheading:8694820-Cattle,
pubmed-meshheading:8694820-Dimyristoylphosphatidylcholine,
pubmed-meshheading:8694820-Drug Carriers,
pubmed-meshheading:8694820-Fluorescent Dyes,
pubmed-meshheading:8694820-Fura-2,
pubmed-meshheading:8694820-Kinetics,
pubmed-meshheading:8694820-Liposomes,
pubmed-meshheading:8694820-Oligopeptides,
pubmed-meshheading:8694820-Phosphatidylglycerols
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pubmed:year |
1996
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pubmed:articleTitle |
Interaction of RGD liposomes with platelets.
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pubmed:affiliation |
Artificial Cells and Organs Research Centre, McGill University, Montreal, Quebec, Canada.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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