| pubmed-article:8694804 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8694804 | lifeskim:mentions | umls-concept:C0123759 | lld:lifeskim |
| pubmed-article:8694804 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:8694804 | lifeskim:mentions | umls-concept:C1864814 | lld:lifeskim |
| pubmed-article:8694804 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8694804 | pubmed:dateCreated | 1996-8-29 | lld:pubmed |
| pubmed-article:8694804 | pubmed:abstractText | Interleukin-12 is a heterodimeric cytokine, mainly produced by macrophages. In our present study we demonstrate that interleukin-12 expression is regulated by nitric oxide. Incubation of the macrophage cell line IC 21 with interferon-gamma gave rise to both interleukin-12 p40 mRNA and nitric oxide production. The concurrent addition of the nitric oxide synthase inhibitor N(G)-monomethyl-L-arginine inhibited nitrite production and in parallel completely suppressed interleukin-12 p40 mRNA formation. This indicated that endogenous nitric oxide synthase activity was required for IL-12 p40 gene expression. Exposure of the cells towards the nitric oxide generating compounds nitroprusside or S-nitroso-N-acetyl-penicillamine induced interleukin-12 p40 mRNA. Maximal mRNA levels were induced with nitric oxide donors at 1 microM concentration. We conclude that nitric oxide may exert an autoregulatory and paracrine control of interleukin-12 gene expression. | lld:pubmed |
| pubmed-article:8694804 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8694804 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8694804 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8694804 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8694804 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8694804 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:8694804 | pubmed:author | pubmed-author:KolbHH | lld:pubmed |
| pubmed-article:8694804 | pubmed:author | pubmed-author:HartmannBB | lld:pubmed |
| pubmed-article:8694804 | pubmed:author | pubmed-author:RotheHH | lld:pubmed |
| pubmed-article:8694804 | pubmed:author | pubmed-author:GeerlingsPP | lld:pubmed |
| pubmed-article:8694804 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8694804 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:8694804 | pubmed:volume | 224 | lld:pubmed |
| pubmed-article:8694804 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8694804 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8694804 | pubmed:pagination | 159-63 | lld:pubmed |
| pubmed-article:8694804 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:8694804 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8694804 | pubmed:articleTitle | Interleukin-12 gene-expression of macrophages is regulated by nitric oxide. | lld:pubmed |
| pubmed-article:8694804 | pubmed:affiliation | Diabetes Research Institute, Heinrich- Heine University of Düsseldorf, Germany. | lld:pubmed |
| pubmed-article:8694804 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8694804 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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