Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1996-8-29
|
| pubmed:abstractText |
This study was performed to investigate whether a fraction of hydroxyethyl starch macromolecules, prepared from pentastarch and known as "Hes-Pz," with molecular weights of 100,000-1,000,000, protects against blood-brain barrier (BBB) disruption due to intracarotid injection of hyperosmolar mannitol. Rats were anesthetized with isoflurane, and retrograde catheterization of a unilateral eternal carotid artery was performed. Except for the Control group (n = 8), hemodilution was performed using lactated Ringer's solution LR group, n = 7), 6% hetastarch (HES group, n = 7), or 6% HES-Pz (HES-Pz group, n = 8) to reduce the hematocrit to about 23%. The BBB transfer coefficient (Ki) of 14C-alpha-aminoisobutyric acid was determined after a unilateral intracarotid injection of 25% mannitol. Blood pressure and hematocrit were similar in all groups. In the control group, Ki was increased significantly in the ipsilateral cortex (IC) where mannitol was injected (16.3 +/- 6.1 vs 4.1 +/- 1.4 microL.min-1) when compared with the contralateral cortex (CC). Ki was similar in the CC in all four groups. The Ki in the IC was significantly lower in the HES-Pz(6.4 +/- 3.5 microL.g-1.min-1) than in the Control, HES, or LR group (16.3 +/- 6.1, 19.0 +/- 12.9, 17.9 +/- 10.8 microL.g-1.min-1, respectively). Our data suggest that HES-Pz significantly attenuates disruption of the BBB caused by an injection of hyperosmolar mannitol.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aminoisobutyric Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Carbon Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Diuretics, Osmotic,
http://linkedlifedata.com/resource/pubmed/chemical/Hetastarch,
http://linkedlifedata.com/resource/pubmed/chemical/Isotonic Solutions,
http://linkedlifedata.com/resource/pubmed/chemical/Macromolecular Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Mannitol,
http://linkedlifedata.com/resource/pubmed/chemical/Plasma Substitutes,
http://linkedlifedata.com/resource/pubmed/chemical/Ringer's lactate
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0003-2999
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
83
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
336-41
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8694315-Aminoisobutyric Acids,
pubmed-meshheading:8694315-Animals,
pubmed-meshheading:8694315-Blood Pressure,
pubmed-meshheading:8694315-Blood-Brain Barrier,
pubmed-meshheading:8694315-Carbon Radioisotopes,
pubmed-meshheading:8694315-Carotid Arteries,
pubmed-meshheading:8694315-Cerebral Cortex,
pubmed-meshheading:8694315-Diuretics, Osmotic,
pubmed-meshheading:8694315-Hematocrit,
pubmed-meshheading:8694315-Hemodilution,
pubmed-meshheading:8694315-Hetastarch,
pubmed-meshheading:8694315-Injections, Intra-Arterial,
pubmed-meshheading:8694315-Isotonic Solutions,
pubmed-meshheading:8694315-Macromolecular Substances,
pubmed-meshheading:8694315-Male,
pubmed-meshheading:8694315-Mannitol,
pubmed-meshheading:8694315-Molecular Weight,
pubmed-meshheading:8694315-Osmolar Concentration,
pubmed-meshheading:8694315-Plasma Substitutes,
pubmed-meshheading:8694315-Rats
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Hydroxyethyl starch solution attenuates blood-brain barrier disruption caused by intracarotid injection of hyperosmolar mannitol in rats.
|
| pubmed:affiliation |
Department of Anesthesia, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick, New Jersey 08901-1977, USA.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|