| pubmed-article:8690043 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8690043 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8690043 | lifeskim:mentions | umls-concept:C0083031 | lld:lifeskim |
| pubmed-article:8690043 | lifeskim:mentions | umls-concept:C0005953 | lld:lifeskim |
| pubmed-article:8690043 | lifeskim:mentions | umls-concept:C0162597 | lld:lifeskim |
| pubmed-article:8690043 | lifeskim:mentions | umls-concept:C0002199 | lld:lifeskim |
| pubmed-article:8690043 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:8690043 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:8690043 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:8690043 | pubmed:dateCreated | 1996-8-23 | lld:pubmed |
| pubmed-article:8690043 | pubmed:abstractText | Interleukin-11 (IL-11), which has been detected as a stromal cell-derived cytokine, regulates multiple steps of early hematopoiesis. Synthesis of IL-11 is induced by IL-1 and transforming growth factor-beta (TGF-beta) in stromal cells and fibroblasts, but the cytokines that inhibit its production remain to be defined. In the present study, we demonstrate that interferon-alpha (INF-alpha) downregulates IL-1-induced IL-11 in human bone marrow stromal cultures. In Northern blot experiments, expression of IL-11 mRNA was reduced in the presence of INF-alpha; this inhibiton was prevented by the addition of cycloheximide. In eight independent experiments, IL-1-stimulated production of IL-11 was significantly inhibited by INF-alpha (p = 0.0117) as measured in stromal cell supernatants by specific enzyme-linked immunosorbent assay (ELISA). Dose titration experiments revealed a dose-dependent inhibition already beginning at a dose level of 10 U/mL IFN. These results are in keeping with our previous observation defining an inhibitory role of INF-alpha in the production of hematopoietic growth factors produced by the bone marrow microenvironment. | lld:pubmed |
| pubmed-article:8690043 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8690043 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8690043 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8690043 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8690043 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8690043 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8690043 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8690043 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8690043 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8690043 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8690043 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8690043 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8690043 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8690043 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8690043 | pubmed:issn | 0301-472X | lld:pubmed |
| pubmed-article:8690043 | pubmed:author | pubmed-author:HuberCC | lld:pubmed |
| pubmed-article:8690043 | pubmed:author | pubmed-author:PeschelCC | lld:pubmed |
| pubmed-article:8690043 | pubmed:author | pubmed-author:AulitzkyW EWE | lld:pubmed |
| pubmed-article:8690043 | pubmed:author | pubmed-author:BunHH | lld:pubmed |
| pubmed-article:8690043 | pubmed:author | pubmed-author:BERGJ LJL | lld:pubmed |
| pubmed-article:8690043 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8690043 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:8690043 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8690043 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8690043 | pubmed:pagination | 863-7 | lld:pubmed |
| pubmed-article:8690043 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:8690043 | pubmed:meshHeading | pubmed-meshheading:8690043-... | lld:pubmed |
| pubmed-article:8690043 | pubmed:meshHeading | pubmed-meshheading:8690043-... | lld:pubmed |
| pubmed-article:8690043 | pubmed:meshHeading | pubmed-meshheading:8690043-... | lld:pubmed |
| pubmed-article:8690043 | pubmed:meshHeading | pubmed-meshheading:8690043-... | lld:pubmed |
| pubmed-article:8690043 | pubmed:meshHeading | pubmed-meshheading:8690043-... | lld:pubmed |
| pubmed-article:8690043 | pubmed:meshHeading | pubmed-meshheading:8690043-... | lld:pubmed |
| pubmed-article:8690043 | pubmed:meshHeading | pubmed-meshheading:8690043-... | lld:pubmed |
| pubmed-article:8690043 | pubmed:meshHeading | pubmed-meshheading:8690043-... | lld:pubmed |
| pubmed-article:8690043 | pubmed:meshHeading | pubmed-meshheading:8690043-... | lld:pubmed |
| pubmed-article:8690043 | pubmed:meshHeading | pubmed-meshheading:8690043-... | lld:pubmed |
| pubmed-article:8690043 | pubmed:meshHeading | pubmed-meshheading:8690043-... | lld:pubmed |
| pubmed-article:8690043 | pubmed:meshHeading | pubmed-meshheading:8690043-... | lld:pubmed |
| pubmed-article:8690043 | pubmed:meshHeading | pubmed-meshheading:8690043-... | lld:pubmed |
| pubmed-article:8690043 | pubmed:meshHeading | pubmed-meshheading:8690043-... | lld:pubmed |
| pubmed-article:8690043 | pubmed:meshHeading | pubmed-meshheading:8690043-... | lld:pubmed |
| pubmed-article:8690043 | pubmed:meshHeading | pubmed-meshheading:8690043-... | lld:pubmed |
| pubmed-article:8690043 | pubmed:meshHeading | pubmed-meshheading:8690043-... | lld:pubmed |
| pubmed-article:8690043 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8690043 | pubmed:articleTitle | Inhibition of interleukin-11 by interferon-alpha in human bone marrow stromal cells. | lld:pubmed |
| pubmed-article:8690043 | pubmed:affiliation | III Department of Internal Medicine, Johannes-Gutenberg-University, School of Medicine, Mainz, Germany. | lld:pubmed |
| pubmed-article:8690043 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8690043 | lld:pubmed |
