| pubmed-article:8688081 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8688081 | lifeskim:mentions | umls-concept:C0031727 | lld:lifeskim |
| pubmed-article:8688081 | lifeskim:mentions | umls-concept:C0056695 | lld:lifeskim |
| pubmed-article:8688081 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:8688081 | lifeskim:mentions | umls-concept:C1419744 | lld:lifeskim |
| pubmed-article:8688081 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:8688081 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:8688081 | lifeskim:mentions | umls-concept:C0017255 | lld:lifeskim |
| pubmed-article:8688081 | lifeskim:mentions | umls-concept:C1948027 | lld:lifeskim |
| pubmed-article:8688081 | pubmed:issue | 5277 | lld:pubmed |
| pubmed-article:8688081 | pubmed:dateCreated | 1996-9-10 | lld:pubmed |
| pubmed-article:8688081 | pubmed:abstractText | A signaling pathway has been elucidated whereby growth factors activate the transcription factor cyclic adenosine monophosphate response element-binding protein (CREB), a critical regulator of immediate early gene transcription. Growth factor-stimulated CREB phosphorylation at serine-133 is mediated by the RAS-mitogen-activated protein kinase (MAPK) pathway. MAPK activates CREB kinase, which in turn phosphorylates and activates CREB. Purification, sequencing, and biochemical characterization of CREB kinase revealed that it is identical to a member of the pp90(RSK) family, RSK2. RSK2 was shown to mediate growth factor induction of CREB serine-133 phosphorylation both in vitro and in vivo. These findings identify a cellular function for RSK2 and define a mechanism whereby growth factor signals mediated by RAS and MAPK are transmitted to the nucleus to activate gene expression. | lld:pubmed |
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| pubmed-article:8688081 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8688081 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8688081 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8688081 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8688081 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:8688081 | pubmed:author | pubmed-author:GreenbergM... | lld:pubmed |
| pubmed-article:8688081 | pubmed:author | pubmed-author:GintyD DDD | lld:pubmed |
| pubmed-article:8688081 | pubmed:author | pubmed-author:XingJJ | lld:pubmed |
| pubmed-article:8688081 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8688081 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:8688081 | pubmed:volume | 273 | lld:pubmed |
| pubmed-article:8688081 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8688081 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8688081 | pubmed:pagination | 959-63 | lld:pubmed |
| pubmed-article:8688081 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:8688081 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8688081 | pubmed:articleTitle | Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. | lld:pubmed |
| pubmed-article:8688081 | pubmed:affiliation | Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA. | lld:pubmed |
| pubmed-article:8688081 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8688081 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8688081 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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