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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5277
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pubmed:dateCreated |
1996-9-10
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pubmed:abstractText |
A signaling pathway has been elucidated whereby growth factors activate the transcription factor cyclic adenosine monophosphate response element-binding protein (CREB), a critical regulator of immediate early gene transcription. Growth factor-stimulated CREB phosphorylation at serine-133 is mediated by the RAS-mitogen-activated protein kinase (MAPK) pathway. MAPK activates CREB kinase, which in turn phosphorylates and activates CREB. Purification, sequencing, and biochemical characterization of CREB kinase revealed that it is identical to a member of the pp90(RSK) family, RSK2. RSK2 was shown to mediate growth factor induction of CREB serine-133 phosphorylation both in vitro and in vivo. These findings identify a cellular function for RSK2 and define a mechanism whereby growth factor signals mediated by RAS and MAPK are transmitted to the nucleus to activate gene expression.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
273
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
959-63
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8688081-Amino Acid Sequence,
pubmed-meshheading:8688081-Animals,
pubmed-meshheading:8688081-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:8688081-Cell Line,
pubmed-meshheading:8688081-Cell Nucleus,
pubmed-meshheading:8688081-Cyclic AMP Response Element-Binding Protein,
pubmed-meshheading:8688081-Epidermal Growth Factor,
pubmed-meshheading:8688081-Gene Expression Regulation,
pubmed-meshheading:8688081-Growth Substances,
pubmed-meshheading:8688081-Humans,
pubmed-meshheading:8688081-Molecular Sequence Data,
pubmed-meshheading:8688081-Nerve Growth Factors,
pubmed-meshheading:8688081-PC12 Cells,
pubmed-meshheading:8688081-Phosphorylation,
pubmed-meshheading:8688081-Protein-Serine-Threonine Kinases,
pubmed-meshheading:8688081-Rats,
pubmed-meshheading:8688081-Ribosomal Protein S6 Kinases,
pubmed-meshheading:8688081-Signal Transduction,
pubmed-meshheading:8688081-Tetradecanoylphorbol Acetate,
pubmed-meshheading:8688081-Transcriptional Activation,
pubmed-meshheading:8688081-Transfection,
pubmed-meshheading:8688081-Tumor Cells, Cultured,
pubmed-meshheading:8688081-ras Proteins
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pubmed:year |
1996
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pubmed:articleTitle |
Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase.
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pubmed:affiliation |
Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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