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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1996-8-16
|
| pubmed:abstractText |
MIP-1 alpha is a secreted chemokine which can inhibit hematopoietic stem cells and modulate inflammatory responses. It is also an inhibitor of HIV replication in CD8+ T-cells. The expression of MIP-1 alpha is induced during cellular activation of CD4+ T-cells and monocytes. It is also expressed in transformed B-cells. We have previously identified a new transcription factor family (the MNP family) whose expression is crucial for the induction of MIP-1 alpha transcription during cellular activation and in transformed B cells. Monocytes and transformed B-cells normally express MNP-1 strongly and MNP-2 weakly, while T-cells strongly express only MNP-2. Recently, we reported that HIV-1 tat downregulates MIP-1 alpha expression in Jurkat T-cells. In this report we show induction of MNP-1 in Jurkat T-cells expressing HIV-1 tat. Expression of neither HTLV-1 tax in Jurkat T-cells nor EBV in B-cells had any effect on MNP-1 or MNP-2 expression, showing that the effect is specific for HIV-1 tat. We propose that HIV-1 tat may inhibit MIP-1 alpha expression by inducing MNP-1 expression in T-cells, probably by either competing with MNP-2 for binding to the MIP-1 alpha promoter or by sequestering it into inactive forms.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL4,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Macrophage Inflammatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Monokines,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0006-291X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
25
|
| pubmed:volume |
223
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
526-33
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8687429-B-Lymphocytes,
pubmed-meshheading:8687429-Base Sequence,
pubmed-meshheading:8687429-Blood Cells,
pubmed-meshheading:8687429-Cell Line,
pubmed-meshheading:8687429-Cell Line, Transformed,
pubmed-meshheading:8687429-Chemokine CCL4,
pubmed-meshheading:8687429-DNA Primers,
pubmed-meshheading:8687429-Gene Expression Regulation, Viral,
pubmed-meshheading:8687429-Genes, tat,
pubmed-meshheading:8687429-Growth Inhibitors,
pubmed-meshheading:8687429-HIV-1,
pubmed-meshheading:8687429-Humans,
pubmed-meshheading:8687429-Lymphocyte Activation,
pubmed-meshheading:8687429-Macrophage Inflammatory Proteins,
pubmed-meshheading:8687429-Molecular Sequence Data,
pubmed-meshheading:8687429-Monocytes,
pubmed-meshheading:8687429-Monokines,
pubmed-meshheading:8687429-Polymerase Chain Reaction,
pubmed-meshheading:8687429-T-Lymphocytes,
pubmed-meshheading:8687429-Transcription Factors,
pubmed-meshheading:8687429-Tumor Cells, Cultured
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
HIV-1 tat induces the expression of a new hematopoietic cell-specific transcription factor and downregulates MIP-1 alpha gene expression in activated T-cells.
|
| pubmed:affiliation |
Department of Biology, University of West Florida, Pensacola 32514, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|