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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1996-8-21
|
| pubmed:abstractText |
Infection by human T-lymphotropic virus type I (HTLV-I) is associated with adult T-cell leukemia and a slowly progressive disease of the central nervous system (CNS), HTLV-I-associated myelopathy/tropical spastic paraparesis, characterized pathologically by inflammation and white matter degeneration in the spinal cord. One of the explanations for the tissue destruction is that HTLV-I infects cells in the CNS, or HTLV-I-infected CD4+ T lymphocytes enter the CNS, and this drives local expansion of virus-specific CD8+ cytotoxic T lymphocytes, which along with cytokines cause the pathological changes. Because both in the circulation and in the cerebrospinal fluid, CD8+ cytotoxic T lymphocytes are primarily reactive to the product of the HTLV-I tax gene, we sought evidence of expression of this gene within cells in the inflammatory lesions. After using double-label in situ hybridization techniques, we now report definitive localization of HTLV-I tax gene expression in CD4+ T lymphocytes in areas of inflammation and white matter destruction. These findings lend support to a hypothetical scheme of neuropathogenesis in which HTLV-I tax gene expression provokes and sustains an immunopathological process that progressively destroys myelin and axons in the spinal cord.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0364-5134
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
40
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
84-90
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8687197-Adult,
pubmed-meshheading:8687197-Aged,
pubmed-meshheading:8687197-Base Sequence,
pubmed-meshheading:8687197-Brain,
pubmed-meshheading:8687197-CD4-Positive T-Lymphocytes,
pubmed-meshheading:8687197-Cells, Cultured,
pubmed-meshheading:8687197-Culture Techniques,
pubmed-meshheading:8687197-Female,
pubmed-meshheading:8687197-Gene Expression,
pubmed-meshheading:8687197-Genes, pX,
pubmed-meshheading:8687197-Humans,
pubmed-meshheading:8687197-Immunohistochemistry,
pubmed-meshheading:8687197-In Situ Hybridization,
pubmed-meshheading:8687197-Leukemia, T-Cell,
pubmed-meshheading:8687197-Male,
pubmed-meshheading:8687197-Molecular Sequence Data,
pubmed-meshheading:8687197-Paraparesis, Tropical Spastic,
pubmed-meshheading:8687197-RNA, Messenger,
pubmed-meshheading:8687197-RNA, Viral,
pubmed-meshheading:8687197-Spinal Cord
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Human T-lymphotropic virus type I-associated myelopathy and tax gene expression in CD4+ T lymphocytes.
|
| pubmed:affiliation |
Department of Microbiology, University of Minnesota, Minneapolis, 55455, USA.
|
| pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|