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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1996-8-21
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pubmed:abstractText |
The endothelial and smooth muscle integrin alphaVbeta3, a receptor for vitronectin and fibrinogen, participates in angiogenesis associated with wound healing and tumorigenicity. The microvascular expression of alphavbeta3 and fibrin during experimental middle cerebral artery occlusion and reperfusion in a nonhuman primate model was examined by computer-assisted video imaging microscopy. No microvascular expression of alphavbeta3 was seen in the control subjects (n = 3) or the non-ischemic basal ganglia of subjects undergoing 2-hour MCA:O (middle cerebral artery occlusion) or 3-hour occlusion with 1-hour (n = 3), 4-hour (n = 3), and 24-hour (n = 3) reperfusion. In the ischemic territory, alphavbeta3 appeared initially at 2 hours of middle cerebral artery occlusion. Up-regulation of alphavbeta3 was confined to the media of 30.0- to 50.0-micron-diameter arterioles in the ischemic core and correlated significantly with fibrin deposition in those vessels (P < 0.0005). Integrin alphavbeta3 and its ligand fibrinogen appear in a subpopulation of microvessels after focal cerebral ischemia.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8686760-1287878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8686760-1693772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8686760-1697296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8686760-1703545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8686760-1717171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8686760-1926239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8686760-1974032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8686760-2305408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8686760-2433615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8686760-2441302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8686760-2442758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8686760-2447074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8686760-2467745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8686760-2479539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8686760-2848850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8686760-3161894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8686760-3343338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8686760-3726541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8686760-3810730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8686760-7207743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8686760-7512751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8686760-7522656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8686760-7528107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8686760-7532190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8686760-7785890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8686760-8023366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8686760-8073468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8686760-8291608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8686760-8506556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8686760-8786382
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0002-9440
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
149
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
37-44
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8686760-Animals,
pubmed-meshheading:8686760-Basal Ganglia,
pubmed-meshheading:8686760-Brain Chemistry,
pubmed-meshheading:8686760-Endothelium, Vascular,
pubmed-meshheading:8686760-Fibrin,
pubmed-meshheading:8686760-Immunohistochemistry,
pubmed-meshheading:8686760-Ischemic Attack, Transient,
pubmed-meshheading:8686760-Male,
pubmed-meshheading:8686760-Microcirculation,
pubmed-meshheading:8686760-Papio,
pubmed-meshheading:8686760-Receptors, Vitronectin,
pubmed-meshheading:8686760-Reperfusion,
pubmed-meshheading:8686760-Up-Regulation
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pubmed:year |
1996
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pubmed:articleTitle |
Integrin alphavbeta3 is expressed in selected microvessels after focal cerebral ischemia.
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pubmed:affiliation |
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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