| pubmed-article:8686513 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8686513 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:8686513 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8686513 | lifeskim:mentions | umls-concept:C0262950 | lld:lifeskim |
| pubmed-article:8686513 | lifeskim:mentions | umls-concept:C0080194 | lld:lifeskim |
| pubmed-article:8686513 | lifeskim:mentions | umls-concept:C0678715 | lld:lifeskim |
| pubmed-article:8686513 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:8686513 | pubmed:dateCreated | 1996-8-20 | lld:pubmed |
| pubmed-article:8686513 | pubmed:abstractText | The immune and skeletal systems are known to interact. We have repeatedly shown that in contrast to in vitro data, the administration of T lymphocyte immunosuppressants, such as cyclosporin A, leads to an increase in bone resorption and a high turnover osteopenia. The purpose of this study was to characterize the bone metabolism of the T lymphocyte deficient Rowett athymic homozygous (rnu/rnu) nude rat. We wished to determine whether these rats share the bone abnormalities of cyclosporin A-treated rats. Eleven 10-week-old Sprague-Dawley rats and 12 similarly aged nude rats were studied over a 4-week period. Metaphyseal cancellous bone histomorphometry was similar in the two groups of rats and only differed with regard to percentage eroded perimeter (lower in nude rats, p = 0.0008) and longitudinal growth rate (49% lower in nude rats, p < 0.001). The nude rats had less body mass (p < 0.001) but nevertheless gained the same percentage of their body weight over the study period. The athymic rats had lower levels of serum, 1,25-dihydroxyvitamin D (p < 0.014) and serum osteocalcin(p < 0.009), and at the age of 14 weeks the nude rats had lower concentrations of serum creatinine (p = 0.001) and blood ionized calcium (p = 0.0002), yet serum PTH was similar throughout. RNA isolated from the contralateral tibias revealed that the nude group had lower steady-state levels of osteocalcin mRNA despite similar rates of bone formation. In its entirety, the data suggest that T cell deficiency per se is not necessarily associated with high turnover osteopenia. | lld:pubmed |
| pubmed-article:8686513 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8686513 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8686513 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8686513 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8686513 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8686513 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8686513 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8686513 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8686513 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8686513 | pubmed:issn | 0884-0431 | lld:pubmed |
| pubmed-article:8686513 | pubmed:author | pubmed-author:EpsteinSS | lld:pubmed |
| pubmed-article:8686513 | pubmed:author | pubmed-author:JeeW SWS | lld:pubmed |
| pubmed-article:8686513 | pubmed:author | pubmed-author:HendyG NGN | lld:pubmed |
| pubmed-article:8686513 | pubmed:author | pubmed-author:LoNN | lld:pubmed |
| pubmed-article:8686513 | pubmed:author | pubmed-author:RucinskiBB | lld:pubmed |
| pubmed-article:8686513 | pubmed:author | pubmed-author:PayntonB VBV | lld:pubmed |
| pubmed-article:8686513 | pubmed:author | pubmed-author:LutzM AMA | lld:pubmed |
| pubmed-article:8686513 | pubmed:author | pubmed-author:BuchinskyF... | lld:pubmed |
| pubmed-article:8686513 | pubmed:author | pubmed-author:BryerH PHP | lld:pubmed |
| pubmed-article:8686513 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8686513 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:8686513 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8686513 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8686513 | pubmed:pagination | 1556-65 | lld:pubmed |
| pubmed-article:8686513 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
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| pubmed-article:8686513 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:8686513 | pubmed:articleTitle | Bone mineral metabolism in T lymphocyte-deficient and -replete strains of rat. | lld:pubmed |
| pubmed-article:8686513 | pubmed:affiliation | Department of Endocrinology and Metabolism, Albert Einstein Medical Center, Philadelphia, Pennsylvania, USA. | lld:pubmed |
| pubmed-article:8686513 | pubmed:publicationType | Journal Article | lld:pubmed |
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