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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1996-8-20
|
| pubmed:abstractText |
The immune and skeletal systems are known to interact. We have repeatedly shown that in contrast to in vitro data, the administration of T lymphocyte immunosuppressants, such as cyclosporin A, leads to an increase in bone resorption and a high turnover osteopenia. The purpose of this study was to characterize the bone metabolism of the T lymphocyte deficient Rowett athymic homozygous (rnu/rnu) nude rat. We wished to determine whether these rats share the bone abnormalities of cyclosporin A-treated rats. Eleven 10-week-old Sprague-Dawley rats and 12 similarly aged nude rats were studied over a 4-week period. Metaphyseal cancellous bone histomorphometry was similar in the two groups of rats and only differed with regard to percentage eroded perimeter (lower in nude rats, p = 0.0008) and longitudinal growth rate (49% lower in nude rats, p < 0.001). The nude rats had less body mass (p < 0.001) but nevertheless gained the same percentage of their body weight over the study period. The athymic rats had lower levels of serum, 1,25-dihydroxyvitamin D (p < 0.014) and serum osteocalcin(p < 0.009), and at the age of 14 weeks the nude rats had lower concentrations of serum creatinine (p = 0.001) and blood ionized calcium (p = 0.0002), yet serum PTH was similar throughout. RNA isolated from the contralateral tibias revealed that the nude group had lower steady-state levels of osteocalcin mRNA despite similar rates of bone formation. In its entirety, the data suggest that T cell deficiency per se is not necessarily associated with high turnover osteopenia.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Calcitriol,
http://linkedlifedata.com/resource/pubmed/chemical/Creatinine,
http://linkedlifedata.com/resource/pubmed/chemical/Minerals,
http://linkedlifedata.com/resource/pubmed/chemical/Osteocalcin,
http://linkedlifedata.com/resource/pubmed/chemical/Parathyroid Hormone
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0884-0431
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1556-65
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8686513-Animals,
pubmed-meshheading:8686513-Blood Glucose,
pubmed-meshheading:8686513-Blood Urea Nitrogen,
pubmed-meshheading:8686513-Body Weight,
pubmed-meshheading:8686513-Bone Density,
pubmed-meshheading:8686513-Bone Development,
pubmed-meshheading:8686513-Bone and Bones,
pubmed-meshheading:8686513-Calcitriol,
pubmed-meshheading:8686513-Creatinine,
pubmed-meshheading:8686513-Lymphopenia,
pubmed-meshheading:8686513-Male,
pubmed-meshheading:8686513-Minerals,
pubmed-meshheading:8686513-Osteocalcin,
pubmed-meshheading:8686513-Parathyroid Hormone,
pubmed-meshheading:8686513-Rats,
pubmed-meshheading:8686513-Rats, Nude,
pubmed-meshheading:8686513-Rats, Sprague-Dawley,
pubmed-meshheading:8686513-T-Lymphocytes
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Bone mineral metabolism in T lymphocyte-deficient and -replete strains of rat.
|
| pubmed:affiliation |
Department of Endocrinology and Metabolism, Albert Einstein Medical Center, Philadelphia, Pennsylvania, USA.
|
| pubmed:publicationType |
Journal Article
|