Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1996-8-20
|
| pubmed:abstractText |
Mono-n-benzyl phthalate (MBeP), one of the major metabolites of the plasticizer n-butyl benzyl phthalate, was evaluated for developmental toxicity in Wistar rats. Rats were given MBeP by gastric intubation at 0, 250, 313, 375, 438 or 500 mg/kg from day 7 through day 15 of pregnancy. Significant decreases in the maternal body weight gains and food consumption during administration period were observed at 313 mg/kg and above and at 250 mg/kg and above, respectively. Significant increase in the incidence of postimplantation loss per litter was found at 438 and 500 mg/kg. The incidences of fetuses with external malformations at 438 mg/kg, of fetuses with skeletal malformations at 313 mg/kg and above and of fetuses with internal malformations at 375 mg/kg and above were higher than those in the control group. Defects in the cervical and thoracic vertebrae, ribs and kidney were frequently observed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0378-4274
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
86
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
19-25
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8685916-Abnormalities, Drug-Induced,
pubmed-meshheading:8685916-Administration, Oral,
pubmed-meshheading:8685916-Animals,
pubmed-meshheading:8685916-Body Weight,
pubmed-meshheading:8685916-Cervical Vertebrae,
pubmed-meshheading:8685916-Dose-Response Relationship, Drug,
pubmed-meshheading:8685916-Eating,
pubmed-meshheading:8685916-Embryo Loss,
pubmed-meshheading:8685916-Embryonic Development,
pubmed-meshheading:8685916-Embryonic and Fetal Development,
pubmed-meshheading:8685916-Female,
pubmed-meshheading:8685916-Kidney,
pubmed-meshheading:8685916-Male,
pubmed-meshheading:8685916-Phthalic Acids,
pubmed-meshheading:8685916-Piloerection,
pubmed-meshheading:8685916-Pregnancy,
pubmed-meshheading:8685916-Rats,
pubmed-meshheading:8685916-Rats, Wistar,
pubmed-meshheading:8685916-Ribs,
pubmed-meshheading:8685916-Thoracic Vertebrae
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Developmental toxicity of mono-n-benzyl phthalate, one of the major metabolites of the plasticizer n-butyl benzyl phthalate, in rats.
|
| pubmed:affiliation |
National Institute of Health Sciences, Osaka Branch, Japan.
|
| pubmed:publicationType |
Journal Article
|