Linked Life Data

8685890

Source:http://linkedlifedata.com/resource/pubmed/id/8685890

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1996-8-21
pubmed:abstractText
The effect of lead exposure on beta2-adrenoceptor density and catecholamine response was studied in 26 male workers and 1 female worker, exposed to lead on average for 6 years. The systolic blood pressure in lead workers (101-160 mmHg, 124.4 +/- 14.7 mmHg) was found to be significantly higher than in controls (97-134 mmHg, 115.4 +/- 10.4 mmHg, p < 0.01) as was plasma norepinephrine (0.51 +/- 0.1 microg/liter vs 0.24 +/- 0.05 microg/liter, p < 0.01). The density of lymphocyte beta2-adrenergic receptors (Bmax) in lead-exposed workers was 86% lower than that in controls (0.15 +/- 0.08 vs 1.08 +/- 0.29 fmol/0.1 x 10(6) cells; p < 0.01). The dissociation constants (Kd) of [125I]iodocyanopindolol were 93.6 +/- 42.6 and 87.9 +/- 42.7 pM in lead-exposed workers and controls, respectively. Multiple linear regression analysis showed that elevation of systolic pressure was closely related to (a) blood lead levels, (b) decreased beta2-adrenergic receptor density, and (c) increased plasma catecholamine levels in lead-exposed workers. Linear regression analysis revealed that both plasma norepinephrine levels and beta2-adrenoceptor density (Bmax) were highly correlated with both systolic blood pressures and blood lead levels in lead-exposed workers, and a highly significant negative correlation was found to exist between Bmax and plasma norepinephrine levels (r = -0.82, p < 0.001). These data therefore demonstrate that there is a close relationship between elevated plasma catecholamine levels, decreased beta2-adrenergic receptors, and elevated blood pressure in lead-exposed workers.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0041-008X
pubmed:author
pubmed:issnType
Print
pubmed:volume
139
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:8685890-Adult, pubmed-meshheading:8685890-Binding Sites, pubmed-meshheading:8685890-Blood Pressure, pubmed-meshheading:8685890-Chromatography, High Pressure Liquid, pubmed-meshheading:8685890-Enzyme Inhibitors, pubmed-meshheading:8685890-Epinephrine, pubmed-meshheading:8685890-Female, pubmed-meshheading:8685890-Heme Oxygenase (Decyclizing), pubmed-meshheading:8685890-Humans, pubmed-meshheading:8685890-Iodocyanopindolol, pubmed-meshheading:8685890-Isotope Labeling, pubmed-meshheading:8685890-Lead, pubmed-meshheading:8685890-Lead Poisoning, pubmed-meshheading:8685890-Linear Models, pubmed-meshheading:8685890-Lymphocytes, pubmed-meshheading:8685890-Male, pubmed-meshheading:8685890-Middle Aged, pubmed-meshheading:8685890-Norepinephrine, pubmed-meshheading:8685890-Occupational Exposure, pubmed-meshheading:8685890-Pindolol, pubmed-meshheading:8685890-Protoporphyrins, pubmed-meshheading:8685890-Radioligand Assay, pubmed-meshheading:8685890-Receptors, Adrenergic, beta-2, pubmed-meshheading:8685890-Spectrophotometry, Atomic
pubmed:year
1996
pubmed:articleTitle
Lymphocyte beta2-adrenergic receptors and plasma catecholamine levels in lead-exposed workers.
pubmed:affiliation
Department of Physiology, Graduate Institute of Medicine, Kaohsiung Medical College, Koahsuing City, Taiwan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't