Linked Life Data

8685169

Source:http://linkedlifedata.com/resource/pubmed/id/8685169

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1996-8-20
pubmed:abstractText
Neutropenia is a common feature in pediatric pratice. Besides the particular etiological aspects in the newborn, neutropenia in a child may be acquired, part of a more complex genetic disease, or an isolated inborn disorder. Primary acquired neutropenia, also called benign chronic neutropenia, is the most frequent cause of chronic neutropenia in children. Infantile agranulocytosis is the main primary congenital neutropenia. Its underlying mechanisms are still unknown. Prevention of repeated infections is the main issue in the management of such patients. This implies careful individual assessment for each patient. Management includes first prophylactic antibiotherapy using trimethoprim-sulfamethoxazole and secondly hematological growth factors (mainly G-CSF). Long-term G-CSF therapy results in a rise in the absolute neutrophil count, a reduction in the rate of infection and an improvement in the patient's quality of life. Severe side effects, including osteoporosis, vasculitis, myelodysplasia or leukemia have been occasionally reported in certain subsets of patients. These features are currently being prospectively assessed in an international register. Use of hematological growth factors must be evaluated for each individual case.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0755-4982
pubmed:author
pubmed:issnType
Print
pubmed:day
24
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
293-8
pubmed:dateRevised
2009-1-13
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
[Congenital and acquired neutropenia in children].
pubmed:affiliation
Département de Pédiatrie, Centre hospitalie, Orléans.
pubmed:publicationType
Journal Article, English Abstract, Review