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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1996-8-16
|
| pubmed:abstractText |
The clinical charts of cancer patients with documented fungal infections hospitalized at G. Gaslini Children's Hospital, Italy, from 1980 to 1990 were reviewed. Thirty-seven episodes developing in 37 patients were identified, based on microbiological and/or histological documentation. Patients' age ranged from 3 months to 18 years (median 7 years). Twenty patients were treated for hematological malignancy and 17 had solid tumor. Seven patients (3 with leukemia and 4 with solid tumours), developed mycosis after bone marrow transplantation procedure. A history of neutropenia in the month preceding the documentation of fungal infection was present in 76% of cases (28 of 37). However, only 16 of 28 (55%) of these patients were still neutropenic at time of diagnosis. In 40% of the cases the fungal infection developed as primary infection not preceded by any febrile and/or infectious episode. Fungemias without evident organ localization accounted for the 40% of episodes with a mortality rate of 20%. The other 22 cases (60%) were classified as invasive mycoses; 9 of these patients died (41%). Mortality was higher among patients with mold infection (5 of 7, 72%), than in those with yeast infection (7 of 29.24%). Molds infections and invasive mycoses were virtually absent in the first part of our period of observation (1980-84), but emerged in the second period (1985-90) when also the incidence rate of fungal disease increased (from 2.67/10,000 person/day to 5.93), probably in relation with extensive construction works and with the implementation of a bone marrow transplantation program.
|
| pubmed:language |
ita
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0391-5387
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
17
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
435-41
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8685000-Adolescent,
pubmed-meshheading:8685000-Age Factors,
pubmed-meshheading:8685000-Aspergillosis,
pubmed-meshheading:8685000-Candidiasis,
pubmed-meshheading:8685000-Child,
pubmed-meshheading:8685000-Child, Preschool,
pubmed-meshheading:8685000-Cohort Studies,
pubmed-meshheading:8685000-Data Interpretation, Statistical,
pubmed-meshheading:8685000-Female,
pubmed-meshheading:8685000-Fusarium,
pubmed-meshheading:8685000-Humans,
pubmed-meshheading:8685000-Infant,
pubmed-meshheading:8685000-Male,
pubmed-meshheading:8685000-Mycoses,
pubmed-meshheading:8685000-Neoplasms,
pubmed-meshheading:8685000-Pichia,
pubmed-meshheading:8685000-Retrospective Studies,
pubmed-meshheading:8685000-Trichosporon
|
| pubmed:articleTitle |
[Fungal infections in pediatric oncology].
|
| pubmed:affiliation |
IV Divisione di Pediatria, Istituto Scientifico Giannina Gaslini di Genova, Italia.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
English Abstract,
Research Support, Non-U.S. Gov't
|