| pubmed-article:8683941 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8683941 | lifeskim:mentions | umls-concept:C0699791 | lld:lifeskim |
| pubmed-article:8683941 | lifeskim:mentions | umls-concept:C0242629 | lld:lifeskim |
| pubmed-article:8683941 | lifeskim:mentions | umls-concept:C0332448 | lld:lifeskim |
| pubmed-article:8683941 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:8683941 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:8683941 | lifeskim:mentions | umls-concept:C0522501 | lld:lifeskim |
| pubmed-article:8683941 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8683941 | pubmed:dateCreated | 1996-8-20 | lld:pubmed |
| pubmed-article:8683941 | pubmed:abstractText | A subset of gastric carcinoma carries Epstein-Barr virus (EBV). The immunophenotypic features of EBV-associated (EBV+) gastric carcinoma, which we have analyzed using 25 EBV+ cases, remain unclear. Frozen tissue samples were stained with antibodies to various immune cell markers. To evaluate the proliferative activity of CD8+ cells, we performed CD8/Ki-67 double staining on paraffin-embedded sections. The results were compared with those in EBV-negative (EBV-) gastric carcinomas. All EBV+ and EBV- gastric carcinoma cells expressed major histocompatibility complex class I, whereas major histocompatibility complex class II expression in tumor cells was more prominent in EBV+ cases. Intercellular adhesion molecule-1 and Fas/APO-1 expression was largely restricted to EBV+ cases. The lymphocytes that infiltrated EBV+ tumor nests were predominantly CD8+ T cells, many of which expressed perforin. Immunoelectron microscopy confirmed a close cell to cell contact between these CD8+ cells and carcinoma cells. CD8+ cells were CD11a+ and CD11b- by flow cytometry performed in one case. The labeling index of Ki-67, the proliferation-associated antigen, in CD8+ cells was 4 times higher in EBV+ cases than in EBV- cases. Our data suggest that these CD8+ cells, which bear a cytotoxic phenotype, are actively proliferating in close contact with EBV+ tumor cells and that the specificity of the CD8+ cells may be directed to EBV and/or cellular antigens expressed by the tumor. This is consistent with a generally favorable prognosis of EBV+ gastric carcinoma. Because the observed T-cell infiltration is insufficient to eradicate the tumor cells, certain immunosuppressive factors were speculated to allow the essentially immunogenic carcinoma cells to establish a macroscopic lesion. | lld:pubmed |
| pubmed-article:8683941 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8683941 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8683941 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8683941 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8683941 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8683941 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8683941 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8683941 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8683941 | pubmed:issn | 0023-6837 | lld:pubmed |
| pubmed-article:8683941 | pubmed:author | pubmed-author:NaitoYY | lld:pubmed |
| pubmed-article:8683941 | pubmed:author | pubmed-author:NaguraHH | lld:pubmed |
| pubmed-article:8683941 | pubmed:author | pubmed-author:SaikiYY | lld:pubmed |
| pubmed-article:8683941 | pubmed:author | pubmed-author:OhtaniHH | lld:pubmed |
| pubmed-article:8683941 | pubmed:author | pubmed-author:MiyazawaMM | lld:pubmed |
| pubmed-article:8683941 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8683941 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:8683941 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8683941 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8683941 | pubmed:pagination | 67-76 | lld:pubmed |
| pubmed-article:8683941 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
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| pubmed-article:8683941 | pubmed:meshHeading | pubmed-meshheading:8683941-... | lld:pubmed |
| pubmed-article:8683941 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8683941 | pubmed:articleTitle | Immunophenotypic characterization of Epstein-Barr virus-associated gastric carcinoma: massive infiltration by proliferating CD8+ T-lymphocytes. | lld:pubmed |
| pubmed-article:8683941 | pubmed:affiliation | Department of Pathology, Tohoku University School of Medicine, Aoba-ku, Sendai, Japan. | lld:pubmed |
| pubmed-article:8683941 | pubmed:publicationType | Journal Article | lld:pubmed |
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