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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1996-8-21
|
| pubmed:abstractText |
The institution of inhaled corticosteroids is generally advocated for effective treatment of patients with asthma. It is yet unknown what is the best time to start inhaled corticosteroid therapy and especially whether delayed introduction is harmful. PHASE 1: In a previous study in patients with asthma and COPD, we found that 2.5 years of treatment with a beta 2-agonist plus inhaled corticosteroid (BA + CS) was more effective in improving the FEV1 and the provocative concentration of histamine causing a 20% reduction in FEV1 (PC20) than treatment with a beta 2-agonist plus anticholinergic (BA + AC) or placebo (BA + PL). PHASE 2: We extended this study with 6 months to investigate whether delayed introduction of inhaled CS therapy (800 micrograms beclomethasone dipropionate) in the groups previously not treated with inhaled CS (BA +/- AC) could also improve FEV1 and PC20 to the same degree. A distinction was made between patients with predominantly asthma (high baseline reversibility, delta FEV1 > or = 9% of predicted), and predominantly COPD (low baseline reversibility, delta FEV1 < 9% of predicted).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0012-3692
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
110
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
35-41
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8681660-Administration, Inhalation,
pubmed-meshheading:8681660-Adolescent,
pubmed-meshheading:8681660-Adrenergic beta-Agonists,
pubmed-meshheading:8681660-Adult,
pubmed-meshheading:8681660-Asthma,
pubmed-meshheading:8681660-Beclomethasone,
pubmed-meshheading:8681660-Bronchial Provocation Tests,
pubmed-meshheading:8681660-Double-Blind Method,
pubmed-meshheading:8681660-Drug Therapy, Combination,
pubmed-meshheading:8681660-Female,
pubmed-meshheading:8681660-Forced Expiratory Volume,
pubmed-meshheading:8681660-Glucocorticoids,
pubmed-meshheading:8681660-Humans,
pubmed-meshheading:8681660-Lung Diseases, Obstructive,
pubmed-meshheading:8681660-Male,
pubmed-meshheading:8681660-Middle Aged,
pubmed-meshheading:8681660-Residual Volume,
pubmed-meshheading:8681660-Terbutaline,
pubmed-meshheading:8681660-Time Factors,
pubmed-meshheading:8681660-Total Lung Capacity
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Is delayed introduction of inhaled corticosteroids harmful in patients with obstructive airways disease (asthma and COPD)? The Dutch CNSLD Study Group. The Dutch Chronic Nonspecific Lung Disease Study Groups.
|
| pubmed:affiliation |
Department of Pulmonary Diseases, University Hospital Dijkzigt, Rotterdam, The Netherlands.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
|