Linked Life Data

8680514

Source:http://linkedlifedata.com/resource/pubmed/id/8680514

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1996-8-21
pubmed:abstractText
Patients with immunodeficiency disorders, including children infected with HIV type 1, are at increased risk to develop a malignancy. Although the exact incidence is not clear, an excess of non-Hodgkin's lymphomas, soft tissue tumors, and, in the case of adolescent girls, cervical carcinomas, has been reported in HIV-infected children. Kaposi's sarcoma is rare in children as compared with HIV-infected adults. To understand the pathogenesis of these disorders, one must take into account the multiple interactions between the immunodeficient host, the cytokine dysregulations, and the concurrent infection with many, potentially oncogenic, viruses. Treatment is often complicated by multiple HIV-associated organ dysfunctions as well as drug interactions and infectious complications secondary to severe immmunosuppression. Nonetheless, preliminary results with dose-intensive short-duration chemotherapeutic regimens have been encouraging, and HIV-infected children who develop cancer are likely to benefit from antineoplastic therapy and supportive care.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1040-8703
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
45-9
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Malignancies in pediatric AIDS.
pubmed:affiliation
Pediatric Branch, National Cancer Institute, Bethesda, MD 20892-1928, USA.
pubmed:publicationType
Journal Article, Review