Linked Life Data

8679903

Source:http://linkedlifedata.com/resource/pubmed/id/8679903

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1996-8-16
pubmed:abstractText
Stimulation of salivary gland secretion by treatment of NOD mice with the beta-adrenergic receptor agonist, isoproterenol, was previously shown to cause a lower accumulation of intracellular cAMP than that found that in BALB/c controls (Hu et al., 1994, Am. J. Physiol. 266: G433). This was, in part, due to decreased levels of beta-adrenergic receptor localized in the plasma membrane. In the present investigation, basal levels of cAMP in the salivary glands of NOD mice were found to be similar to controls, while direct stimulation of adenylate cyclase by incubation of isolated membranes with forskolin showed a reduced cAMP accumulation in NOD mice versus BALB/c control mice. Using direct [3H]-forskolin binding, it was determined that the plasma membranes of NOD mice salivary glands contain reduced levels of membrane-associated adenylate cyclase.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0891-6934
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
137-42
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Decreased levels of adenylate cyclase contribute to the down-regulation of beta-adrenergic signal transduction in the salivary glands of the non-obese diabetic (NOD) mouse.
pubmed:affiliation
Department of Oral Biology, University of Florida, Gainesville 32610, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.