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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3-4
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pubmed:dateCreated |
1996-8-14
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pubmed:abstractText |
Stem cell factor (SCF) interacts with the receptor tyrosine kinase c-Kit and has potent effects on hematopoiesis. We have examined the role of JAK2 in the SCF signal transduction pathway. JAK2 and c-Kit were constitutively associated, and treatment with SCF resulted in rapid and transient tyrosine phosphorylation of JAK2. Incubation of cells with JAK2 antisense oligonucleotides resulted in significant decreases in SCF-induced proliferation. These data suggest that JAK2 plays a role in SCF-induced proliferation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/JAK2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Jak2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Janus Kinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphotyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-kit,
http://linkedlifedata.com/resource/pubmed/chemical/Stem Cell Factor
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pubmed:status |
MEDLINE
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pubmed:issn |
0001-5792
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
95
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
224-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8677747-Animals,
pubmed-meshheading:8677747-Base Sequence,
pubmed-meshheading:8677747-Blotting, Western,
pubmed-meshheading:8677747-Cell Division,
pubmed-meshheading:8677747-Cell Line,
pubmed-meshheading:8677747-DNA, Antisense,
pubmed-meshheading:8677747-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:8677747-Humans,
pubmed-meshheading:8677747-Janus Kinase 2,
pubmed-meshheading:8677747-Mice,
pubmed-meshheading:8677747-Molecular Sequence Data,
pubmed-meshheading:8677747-Phosphoproteins,
pubmed-meshheading:8677747-Phosphorylation,
pubmed-meshheading:8677747-Phosphotyrosine,
pubmed-meshheading:8677747-Protein-Tyrosine Kinases,
pubmed-meshheading:8677747-Proto-Oncogene Proteins,
pubmed-meshheading:8677747-Proto-Oncogene Proteins c-kit,
pubmed-meshheading:8677747-Signal Transduction,
pubmed-meshheading:8677747-Stem Cell Factor,
pubmed-meshheading:8677747-Tumor Cells, Cultured
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pubmed:year |
1996
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pubmed:articleTitle |
JAK2 is constitutively associated with c-Kit and is phosphorylated in response to stem cell factor.
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pubmed:affiliation |
Laboratory of Leukocyte Biology, National Cancer Institute - Frederick Cancer Research and Development Center, Md 21702 (USA).
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pubmed:publicationType |
Journal Article
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