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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1996-8-15
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pubmed:abstractText |
The role of cell-mediated cytotoxicity in the complex pathophysiology of graft-versus-host disease (GVHD) has remained poorly defined for several decades. We transplanted T cells from Fas-ligand (FasL)-defective and perforin-deficient mutant donor mice into lethally irradiated MHC-matched allogeneic recipient mice to characterize the role of cell-mediated cytotoxicity in GVHD. Although recipients of allogeneic FasL-defective donor T cells underwent severe GVHD-associated cachexia, they exhibited only minimal signs of hepatic and cutaneous GVHD pathology. Recipients of perforin-deficient allogeneic donor T cells developed signs of acute GVHD, but the time of onset was significantly delayed. These findings demonstrate that Fas-mediated anti-recipient cytotoxicity may be critical for the development of hepatic and cutaneous GVHD, but is not required for GVHD-associated cachexia. In addition, perforin-mediated anti-recipient cytotoxicity appears to play an important role in the kinetics of GVHD pathophysiology, but is not required for GVHD-associated tissue damage.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-10648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-1515873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-1901455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-1910674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-1910678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-1994250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-2104894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-2230649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-2258608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-2405918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-2884832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-2946780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-3053897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-3316469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-3351436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-363972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-36763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-4155153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-6122004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-6246804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-6388062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-6610701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-6983999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-7051875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-7507960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-7511063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-7518614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-7520535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-7521376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-7689176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-7706720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-8140631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-8164737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-8178361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-8212168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-8597370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8676085-8598497
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
183
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2645-56
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8676085-Animals,
pubmed-meshheading:8676085-Antigens, CD95,
pubmed-meshheading:8676085-Bone Marrow Transplantation,
pubmed-meshheading:8676085-Cytotoxicity, Immunologic,
pubmed-meshheading:8676085-Graft vs Host Disease,
pubmed-meshheading:8676085-Histocompatibility Testing,
pubmed-meshheading:8676085-Immunophenotyping,
pubmed-meshheading:8676085-Lymphocyte Transfusion,
pubmed-meshheading:8676085-Major Histocompatibility Complex,
pubmed-meshheading:8676085-Membrane Glycoproteins,
pubmed-meshheading:8676085-Mice,
pubmed-meshheading:8676085-Mice, Inbred C57BL,
pubmed-meshheading:8676085-Mice, Inbred Strains,
pubmed-meshheading:8676085-Mice, Mutant Strains,
pubmed-meshheading:8676085-Perforin,
pubmed-meshheading:8676085-Pore Forming Cytotoxic Proteins,
pubmed-meshheading:8676085-Skin,
pubmed-meshheading:8676085-T-Lymphocytes,
pubmed-meshheading:8676085-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:8676085-Transplantation, Homologous
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pubmed:year |
1996
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pubmed:articleTitle |
The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice.
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pubmed:affiliation |
Department of Microbiology and Immunology, University of Miami School of Medicine, Florida 33101, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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