| pubmed-article:8676068 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8676068 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:8676068 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:8676068 | lifeskim:mentions | umls-concept:C0007595 | lld:lifeskim |
| pubmed-article:8676068 | lifeskim:mentions | umls-concept:C0241526 | lld:lifeskim |
| pubmed-article:8676068 | lifeskim:mentions | umls-concept:C0221099 | lld:lifeskim |
| pubmed-article:8676068 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8676068 | lifeskim:mentions | umls-concept:C0059386 | lld:lifeskim |
| pubmed-article:8676068 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8676068 | pubmed:dateCreated | 1996-8-15 | lld:pubmed |
| pubmed-article:8676068 | pubmed:abstractText | We used CD28-deficient mice to analyze the importance of CD28 costimulation for the response against Staphylococcal enterotoxin B (SEB) in vivo. CD28 was necessary for the strong expansion of V beta 8+ T cells, but not for deletion. The lack of expansion was not due to a failure of SEB to activate V beta 8+ T cells, as V beta 8+ T cells from both CD28-/- and CD28+/+ mice showed similar phenotypic changes within the first 24 h after SEB injection and cell cycle analysis showed that an equal percentage of V beta 8+ T cells started to proliferate. However, the phenotype and the state of proliferation of V beta 8+ T cells was different at later time points. Furthermore, in CD28-/- mice injection with SEB led to rapid induction of unresponsiveness in SEB responsive T cells, indicated by a drastic reduction of proliferation after secondary SEB stimulation in vitro. Unresponsiveness could also be demonstrated in vivo, as CD28-/- mice produced only marginal amounts of TNF alpha after rechallenge with SEB. In addition CD28-/- mice were protected against a lethal toxic shock induced by a second injection with SEB. Our results indicate that CD28 costimulation is crucial for the T cell-mediated toxicity of SEB and demonstrate that T cell stimulation in the absence of CD28 costimulation induces unresponsiveness in vivo. | lld:pubmed |
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| pubmed-article:8676068 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8676068 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8676068 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8676068 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:8676068 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:8676068 | pubmed:author | pubmed-author:MaoT STS | lld:pubmed |
| pubmed-article:8676068 | pubmed:author | pubmed-author:KündigT MTM | lld:pubmed |
| pubmed-article:8676068 | pubmed:author | pubmed-author:MittrückerH... | lld:pubmed |
| pubmed-article:8676068 | pubmed:author | pubmed-author:BouchardDD | lld:pubmed |
| pubmed-article:8676068 | pubmed:author | pubmed-author:ShahinianAA | lld:pubmed |
| pubmed-article:8676068 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8676068 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8676068 | pubmed:volume | 183 | lld:pubmed |
| pubmed-article:8676068 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8676068 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8676068 | pubmed:pagination | 2481-8 | lld:pubmed |
| pubmed-article:8676068 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8676068 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8676068 | pubmed:articleTitle | Induction of unresponsiveness and impaired T cell expansion by staphylococcal enterotoxin B in CD28-deficient mice. | lld:pubmed |
| pubmed-article:8676068 | pubmed:affiliation | Department of Immunology and Biophysics, Ontario Cancer Institute, University of Toronto, Ontario, Canada. | lld:pubmed |
| pubmed-article:8676068 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8676068 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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