Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1996-8-13
pubmed:abstractText
Adenovirus vectors are capable of high efficiency in vivo arterial gene transfer, and are currently in use as therapeutic agents in animal models of vascular disease. However, despite substantial data on the ability of viruses to cause vascular inflammation and proliferation, and the presence in current adenovirus vectors of viral open reading frames that are translated in vivo, no study has examined the effect of adenovirus vectors alone on the arterial phenotype. In a rabbit model of gene transfer into a normal artery, we examined potential vascular cell activation, inflammation, and neointimal proliferation resulting from exposure to replication-defective adenovirus. Exposure of normal arteries to adenovirus vectors resulted in: (a) pronounced infiltration of T cells throughout the artery wall; (b) upregulation of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in arterial smooth muscle cells; (c) neointimal hyperplasia. These findings were present both 10 and 30 d after gene transfer, with no evidence of a decline in severity over time. Adenovirus vectors have pleiotropic effects on the arterial wall and cause significant pathology. Interpretation of experimental protocols that use adenovirus vectors to address either biological or therapeutic issues should take these observations into account. These observations should also prompt the design of more inert gene transfer vectors.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-1348606, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-1360668, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-1372160, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-1661071, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-1714592, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-1990440, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-3972897, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-6600269, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-7504883, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-7514108, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-7514446, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-7519884, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-7522742, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-7526901, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-7532305, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-7539457, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-7641320, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-7678986, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-7688759, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-7688768, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-7691431, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-7729028, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-7734515, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-7769106, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-7805260, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-7824950, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-7884845, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-7909156, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-7923648, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-7938020, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-7955199, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-8010759, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-8016137, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-8047883, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-8159670, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-8181144, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-8183921, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-8252697, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-8274471, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-8349791, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-8353427, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-8403251, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-8403339, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-8428904, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-8476577, http://linkedlifedata.com/resource/pubmed/commentcorrection/8675667-8477524
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
96
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2955-65
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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