| pubmed-article:8674043 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8674043 | lifeskim:mentions | umls-concept:C0085983 | lld:lifeskim |
| pubmed-article:8674043 | lifeskim:mentions | umls-concept:C0008838 | lld:lifeskim |
| pubmed-article:8674043 | lifeskim:mentions | umls-concept:C2346484 | lld:lifeskim |
| pubmed-article:8674043 | lifeskim:mentions | umls-concept:C1881189 | lld:lifeskim |
| pubmed-article:8674043 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:8674043 | pubmed:dateCreated | 1996-8-12 | lld:pubmed |
| pubmed-article:8674043 | pubmed:abstractText | We report a functional link between expression of the metastasis suppressor gene nm23 and cancer cell sensitivity to the alkylating agent cisplatin. Cisplatin was 2-15-fold more inhibitory to the growth in vitro of nm23 transfectants of the K-1735 TK murine melanoma, MDA-MB-435 human breast carcinoma, and OVCAR-3 human ovarian carcinoma cell lines as compared to matched control transfectants. Administration of a single dose of cisplatin i.v. after injection of control- or nm23-1-transfected K-1735 TK melanoma cells resulted in a more pronounced inhibition of pulmonary metastatic colonization by the nm23-1 transfectants. The mechanism of nm23-dependent sensitivity to cisplatin is unknown, but was correlated with increased formation of interstrand DNA cross-links in nm23-H1 transfected breast carcinoma cells. These data suggest that elevation of tumor cell nm23 expression may be considered as a potential therapeutic strategy in combination with cisplatin treatment. | lld:pubmed |
| pubmed-article:8674043 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8674043 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8674043 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8674043 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8674043 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8674043 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8674043 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:8674043 | pubmed:author | pubmed-author:FergusonA WAW | lld:pubmed |
| pubmed-article:8674043 | pubmed:author | pubmed-author:FlatowUU | lld:pubmed |
| pubmed-article:8674043 | pubmed:author | pubmed-author:SteegP SPS | lld:pubmed |
| pubmed-article:8674043 | pubmed:author | pubmed-author:BohrV AVA | lld:pubmed |
| pubmed-article:8674043 | pubmed:author | pubmed-author:LarminatFF | lld:pubmed |
| pubmed-article:8674043 | pubmed:author | pubmed-author:MacDonaldN... | lld:pubmed |
| pubmed-article:8674043 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8674043 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8674043 | pubmed:volume | 56 | lld:pubmed |
| pubmed-article:8674043 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8674043 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8674043 | pubmed:pagination | 2931-5 | lld:pubmed |
| pubmed-article:8674043 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:8674043 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8674043 | pubmed:articleTitle | Increased sensitivity to cisplatin by nm23-transfected tumor cell lines. | lld:pubmed |
| pubmed-article:8674043 | pubmed:affiliation | Women's Cancers Section, Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20892, USA. | lld:pubmed |
| pubmed-article:8674043 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8674043 | pubmed:publicationType | Comparative Study | lld:pubmed |
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