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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
1996-8-12
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pubmed:abstractText |
We report a functional link between expression of the metastasis suppressor gene nm23 and cancer cell sensitivity to the alkylating agent cisplatin. Cisplatin was 2-15-fold more inhibitory to the growth in vitro of nm23 transfectants of the K-1735 TK murine melanoma, MDA-MB-435 human breast carcinoma, and OVCAR-3 human ovarian carcinoma cell lines as compared to matched control transfectants. Administration of a single dose of cisplatin i.v. after injection of control- or nm23-1-transfected K-1735 TK melanoma cells resulted in a more pronounced inhibition of pulmonary metastatic colonization by the nm23-1 transfectants. The mechanism of nm23-dependent sensitivity to cisplatin is unknown, but was correlated with increased formation of interstrand DNA cross-links in nm23-H1 transfected breast carcinoma cells. These data suggest that elevation of tumor cell nm23 expression may be considered as a potential therapeutic strategy in combination with cisplatin treatment.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Alkylating,
http://linkedlifedata.com/resource/pubmed/chemical/Cisplatin,
http://linkedlifedata.com/resource/pubmed/chemical/Cross-Linking Reagents,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Monomeric GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NM23 Nucleoside Diphosphate Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/NME1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nme1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Nucleoside-Diphosphate Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0008-5472
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2931-5
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:8674043-Animals,
pubmed-meshheading:8674043-Antineoplastic Agents, Alkylating,
pubmed-meshheading:8674043-Breast Neoplasms,
pubmed-meshheading:8674043-Cell Division,
pubmed-meshheading:8674043-Cisplatin,
pubmed-meshheading:8674043-Cross-Linking Reagents,
pubmed-meshheading:8674043-DNA, Neoplasm,
pubmed-meshheading:8674043-DNA Damage,
pubmed-meshheading:8674043-Drug Screening Assays, Antitumor,
pubmed-meshheading:8674043-Female,
pubmed-meshheading:8674043-Humans,
pubmed-meshheading:8674043-Melanoma,
pubmed-meshheading:8674043-Mice,
pubmed-meshheading:8674043-Monomeric GTP-Binding Proteins,
pubmed-meshheading:8674043-NM23 Nucleoside Diphosphate Kinases,
pubmed-meshheading:8674043-Neoplasm Proteins,
pubmed-meshheading:8674043-Neoplasms,
pubmed-meshheading:8674043-Nucleoside-Diphosphate Kinase,
pubmed-meshheading:8674043-Ovarian Neoplasms,
pubmed-meshheading:8674043-Transcription Factors,
pubmed-meshheading:8674043-Transfection,
pubmed-meshheading:8674043-Tumor Cells, Cultured
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pubmed:year |
1996
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pubmed:articleTitle |
Increased sensitivity to cisplatin by nm23-transfected tumor cell lines.
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pubmed:affiliation |
Women's Cancers Section, Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20892, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study
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