Linked Life Data

8673005

Source:http://linkedlifedata.com/resource/pubmed/id/8673005

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1996-8-13
pubmed:abstractText
Tumour cells have been reported to contain an activator of platelet heparitinase which is absent from normal cells. Using an assay which measures the degradation of radiolabelled heparin, we observed that lysates of metastatic melanoma cells did activate platelet radiolabelled heparin, we observed that lysates of metastatic melanoma cells did activate platelet heparitinase but that lysates of arterial endothelial and smooth muscle cells did likewise, with the latter being particularly effective. The activator largely survived a 10 min preincubation of the cell lysates at 70 degrees C, but not at 100 degrees C. Experimental results indicated that the contents of 10(5) vascular smooth muscle cells could increase platelet heparitinase activity in vitro to 6 times its initial value. We suggest such activation may have physiological relevance and may even assist the development of certain cardiovascular diseases in man.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1039-9712
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
231-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Activation of platelet heparitinase by vascular cell lysates.
pubmed:affiliation
CSIRO Division of Biomolecular Engineering, Sydney Laboratory, North Ryde, NSW, Australia.
pubmed:publicationType
Journal Article