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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
1996-10-10
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pubmed:abstractText |
In an Escherichia coli mutant devoid of H-NS, a bacterial nucleoid protein, mouse protein Btcd was able to substitute for H-NS in two tested functions. It restored cell motility and repression of the expression of the bgl operon. Btcd1, a mutant Btcd protein deleted of its zinc finger and thus having reduced DNA binding, failed to substitute for H-NS. Mouse protein Btcd was shown to repress the bgl operon at the level of transcription initiation and to bind preferentially to a curved DNA fragment encompassing the bgl promoter. These effects of Btcd on bacterial gene transcription can be accounted for by the binding of Btcd or H-NS to a curved DNA sequence near a promoter. A few mammalian proteins have been shown to substitute for their Escherichia prototypes involved in DNA and RNA transactions. The efficiency of Btcd protein in substituting for H-NS in Escherichia suggests its possible involvement in regulating gene expression in mouse cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670903-1423593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670903-1464328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670903-1482109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670903-1730689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670903-1745240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670903-1903834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670903-1923796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670903-1956768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670903-1997427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670903-2126011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670903-2128526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670903-2177526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670903-2404280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670903-2673534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670903-2830029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670903-3025456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670903-3034860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670903-3057495,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670903-3118156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670903-3301003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670903-3549457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670903-3786134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670903-6266910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670903-6297752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670903-6343787,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/8670903-8355613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670903-8387228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670903-8396044,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/8670903-8468283
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0261-4189
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3986-92
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8670903-Animals,
pubmed-meshheading:8670903-Bacterial Outer Membrane Proteins,
pubmed-meshheading:8670903-Bacterial Proteins,
pubmed-meshheading:8670903-Base Sequence,
pubmed-meshheading:8670903-DNA, Circular,
pubmed-meshheading:8670903-DNA-Binding Proteins,
pubmed-meshheading:8670903-Electrophoresis, Gel, Two-Dimensional,
pubmed-meshheading:8670903-Escherichia coli,
pubmed-meshheading:8670903-Flagella,
pubmed-meshheading:8670903-Gene Expression Regulation, Bacterial,
pubmed-meshheading:8670903-Mice,
pubmed-meshheading:8670903-Molecular Sequence Data,
pubmed-meshheading:8670903-Operon,
pubmed-meshheading:8670903-Promoter Regions, Genetic,
pubmed-meshheading:8670903-Transcription, Genetic,
pubmed-meshheading:8670903-beta-Glucosidase
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pubmed:year |
1996
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pubmed:articleTitle |
Btcd, a mouse protein that binds to curved DNA, can substitute in Escherichia coli for H-NS, a bacterial nucleoid protein.
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pubmed:affiliation |
Groupe d'Etude 'Mutagénèse et Cancérogenèse', Institut Curie, Batiment110, Centre Universitaire, F-91405 Orsay, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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