Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
1996-10-10
pubmed:abstractText
The transcription factor, Nuclear Factor of Activated T cells (NFAT) is a major target for p21ras and calcium signalling pathways in the IL-2 gene and is induced by p21ras signals acting in synergy with calcium/calcineurin signals. One p21ras effector pathway involves the MAP kinase ERK-2, and we have examined its role in NFAT regulation. Expression of dominant negative MAPKK-1 prevents NFAT induction. Constitutively active MAPKK-1 fully activates ERK-2 and the transcription factor Elk-1, but does not substitute for activated p21ras and synergize with calcium/calcineurin signals to induce NFAT. Expression of dominant negative N17Rac also prevents TCR and p21ras activation of NFAT, but without interfering with the ERK-2 pathway. The transcriptional activity of the NFAT binding site is mediated by a complex comprising a member of the NFAT group and AP-1 family proteins. The induction of AP-1 by p21ras also requires Rac-1 function. Activated Rac-1 could mimic activated p21ras to induce AP-1 but not to induce NFAT. Moreover, the combination of activated MAPKK-1 and Rac-1 could not substitute for activated p21ras and synergize with calcium signals to induce NFAT. Thus, p21ras regulation of NFAT in T cells requires the activity of multiple effector pathways including those regulated by MAPKK-1/ERK-2 and Rac-1.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-1330321, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-1425589, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-1537820, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-1658621, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-1715516, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-2394747, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-3461723, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-7536630, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-7540136, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-7600581, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-7600582, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-7600583, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-7618106, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-7651411, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-7697350, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-7700355, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-7718090, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-7730364, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-7744004, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-7749981, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-7797459, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-7809086, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-7834740, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-7835338, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-7843251, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-7854419, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-7911739, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-7972015, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-8006597, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-8052307, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-8068174, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-8072547, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-8089125, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-8107774, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-8137421, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-8193545, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-8202141, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-8205621, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-8293463, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-8332195, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-8376929, http://linkedlifedata.com/resource/pubmed/commentcorrection/8670897-8441422
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Calcium, http://linkedlifedata.com/resource/pubmed/chemical/DNA, http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/HRAS protein, human, http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 1, http://linkedlifedata.com/resource/pubmed/chemical/MAP2K1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase..., http://linkedlifedata.com/resource/pubmed/chemical/NFATC Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins p21(ras), http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/rac GTP-Binding Proteins
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0261-4189
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3923-33
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
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