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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1996-8-27
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pubmed:abstractText |
I factors are LINE-like transposable elements in the genome of Drosophila melanogaster. They normally transpose infrequently but are activated in the germline of female progeny of crosses between males of a strain that contains complete elements, an I or inducer strain and females of a strain that does not, an R or reactive strain. This causes a phenomenon known as I-R hybrid dysgenesis. We have previously shown that the I factor promoter lies between nucleotides 1 and 30. Here we demonstrate that expression of this promoter is regulated by nucleotides 41-186 of the I factor. This sequence can act as an enhancer as it stimulates expression of the hsp7O promoter in ovaries in the absence of heat-shock. Within this region there is a site that is required for promoter activity and that is recognized by a sequence-specific binding protein. We propose that this protein contributes to the enhancer activity of nucleotides 41-186 and that reduced I factor expression in inducer strains is due to titration of this protein or others that interact with it.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670818-1330483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670818-1592002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670818-1647020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670818-1698618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670818-1710982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670818-2154679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670818-2161558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670818-2164887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670818-2430722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670818-2543105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670818-2559652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670818-2851098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670818-3000622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670818-3108854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670818-3246353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670818-3356339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670818-6289436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670818-7565601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670818-7713426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670818-7758951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670818-7813907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670818-7925283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670818-7958851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670818-8074994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670818-8157003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670818-817964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670818-8232194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670818-8380889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670818-8575672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8670818-942051
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0261-4189
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3174-81
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8670818-Animals,
pubmed-meshheading:8670818-Base Sequence,
pubmed-meshheading:8670818-DNA Primers,
pubmed-meshheading:8670818-DNA Transposable Elements,
pubmed-meshheading:8670818-Drosophila melanogaster,
pubmed-meshheading:8670818-Enhancer Elements, Genetic,
pubmed-meshheading:8670818-Female,
pubmed-meshheading:8670818-Gene Expression Regulation, Developmental,
pubmed-meshheading:8670818-HSP70 Heat-Shock Proteins,
pubmed-meshheading:8670818-Male,
pubmed-meshheading:8670818-Molecular Sequence Data,
pubmed-meshheading:8670818-Ovary,
pubmed-meshheading:8670818-Promoter Regions, Genetic
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pubmed:year |
1996
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pubmed:articleTitle |
Control of expression of the I factor, a LINE-like transposable element in Drosophila melanogaster.
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pubmed:affiliation |
Institute of Cell and Molecular Biology, University of Edinburgh, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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