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rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
2
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|
pubmed:dateCreated |
1996-8-8
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|
pubmed:abstractText |
6-Bromoflavone, obtained by bromination of flavanone, binds to central benzodiazepine receptors with a Ki=70 nM and has a clear anxiolytic activity in mice, at 0.5 mg/kg i.p. A survey of the structure/affinity relationship for those receptors in a series of natural and synthetic flavonoids is presented.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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|
pubmed:status |
MEDLINE
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pubmed:month |
Jun
|
|
pubmed:issn |
0006-291X
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:day |
14
|
|
pubmed:volume |
223
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
384-9
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|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8670291-Affinity Labels,
pubmed-meshheading:8670291-Analysis of Variance,
pubmed-meshheading:8670291-Animals,
pubmed-meshheading:8670291-Anti-Anxiety Agents,
pubmed-meshheading:8670291-Flavonoids,
pubmed-meshheading:8670291-Flunitrazepam,
pubmed-meshheading:8670291-Kinetics,
pubmed-meshheading:8670291-Maze Learning,
pubmed-meshheading:8670291-Mice,
pubmed-meshheading:8670291-Molecular Structure,
pubmed-meshheading:8670291-Motor Activity,
pubmed-meshheading:8670291-Receptors, GABA-A,
pubmed-meshheading:8670291-Structure-Activity Relationship,
pubmed-meshheading:8670291-gamma-Aminobutyric Acid
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|
pubmed:year |
1996
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|
pubmed:articleTitle |
6-Bromoflavone, a high affinity ligand for the central benzodiazepine receptors is a member of a family of active flavonoids.
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pubmed:affiliation |
Instituto de Química y Fisicoquímica Biológicas, Facultad de Farmaciay Bioquímica, Buenos Aires, Argentina.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
