Linked Life Data

8670214

Source:http://linkedlifedata.com/resource/pubmed/id/8670214

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1996-8-6
pubmed:abstractText
The interaction between Trypanosoma cruzi, the protozoan causative of Chagas's disease, and its host cell is a complex process in which multiple signals including those of Ca2+ are involved. Macrophage cytosolic Ca2+ levels were studied during the interaction of these cells with metacyclic trypomastigotes of T. cruzi, since this event is an initial step in the natural infection. In this model we detected an increase in the macrophage cytosolic Ca2+ concentration after infection, or incubation with a metacyclic lysate or with isolated membranes, suggesting that these increments could be necessary for parasite invasion. This fact was confirmed by treating macrophages with a Ca2+ chelator or a Ca2+ channel antagonist which decreased the infection percentages while parasitization levels increased after treatment with Ca2+ channel agonist.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
222
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
386-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Trypanosoma cruzi: participation of intracellular Ca2+ during metacyclic trypomastigote-macrophage interaction.
pubmed:affiliation
Departamento de Microbiología, Facultad de Medicina, Universidad de Buenos Aires, Argentina.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't