Linked Life Data

8669869

Source:http://linkedlifedata.com/resource/pubmed/id/8669869

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6B
pubmed:dateCreated
1996-8-7
pubmed:abstractText
Neutrophil and monocyte phagocytic functions, i.e % of phagocytic cells, ingestion and intracellular microbe killing were determined in 51 patients with colorectal adenocarcinoma, 43 with localized disease and 8 with distant metastases. Phagocytic functions were determined at the time of diagnosis, following surgery are before each of 6 cycles of fluorouracil chemotherapy. Four of six phagocytic parameters determined were decreased at diagnosis while all 6 decreased following surgery. During chemotherapy, neutrophil phagocytic activity recovered to normal value while all other neutrophil and monocyte functions remained decreased. Even so, neutrophil ingestion and monocyte phagocytic and bactericidal activities increased reaching from time to time values significantly higher than that found before the start of chemotherapy. The results showed significant alterations of neutrophil and monocyte phagocytosis in colorectal adenocarcinoma patients at the time of diagnosis, with further decrease following surgery. Fluorouracil chemotherapy did not exert suppressive effects on these functions; on the contrary, it seemed to support, or at least not to prevent, their partial recovery.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2805-9
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:articleTitle
Neutrophil and monocyte phagocytic functions in patients with colorectal adenocarcinoma during fluorouracil therapy.
pubmed:affiliation
Department of Oncology and Nuclear medicine, University Hospital Sestre milosrdnice, HR-Zagreb, Croatia.
pubmed:publicationType
Journal Article