Linked Life Data

8669832

Source:http://linkedlifedata.com/resource/pubmed/id/8669832

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6B
pubmed:dateCreated
1996-8-7
pubmed:abstractText
The effect of hyperthermia and cytokine (IFN-gamma) in the expression of carcinoembryonic antigen (CEA) on the surface of cells was studied in vitro. The human lung cancer cell line, GLL-1, was used. The results demonstrate increase in CEA expression after hyperthermia. The magnitude of elevated CEA expression increased with increasing temperature (41-43 degrees C). Time-course study demonstrated that the peak CEA expression was 3 days after heating at 43 degrees C. The relative CEA expression was 1.3 at 1 day, 1.6 at 2 days, 1.9 at 3 days, 1.8 at 4 days, and 1.5 at 5 days, respectively. Hyperthermia plus IFN-gamma showed a synergistic effect in the expression of CEA. The four fold marked increase of CEA expression was detected. Furthermore, the pattern of time-course of CEA expression in hyperthermia combined with IFN-gamma was different from that in hyperthermia alone.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2601-6
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:articleTitle
Modifications of tumor-associated antigen expression on human lung cancer cells by hyperthermia and cytokine.
pubmed:affiliation
Department of Radiology and Radiation Oncology, Gunma University School of Medicine, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't